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Storage Disorders 1283.e1

Storage Disorders
VetBooks.ir Lysosomal Storage Disorders

Species/Breed Age of Onset Duration Signs/Pathologic Examination
Neuronal Disorders
GM1 Gangliosidosis (Betagalactosidase Deficiency)
Feline 4-6 months 6-10 months Ataxia, tremors, paresis, visual loss, seizures, behavioral changes; corneal
Siamese, Korat, mixed breeds and retinal lesions; CNS, liver, pancreatic acinar cells involved
Canine 2-4 months 4-6 months Visual signs, tremors, dysmetria, paresis, behavioral changes; CNS, liver,
Beagle/mixed kidney, spleen, lymph nodes
Canine 6 months 18 months Behavioral changes, seizures, ataxia, weakness, visual signs, coma; CNS
German short-haired pointers
Feline 4-10 weeks Tremors, dysmetria, ataxia, paresis; dwarfism, corneal opacity; CNS, liver,
DSH endothelium, bone marrow, spleen, kidney
Sphingomyelin Lipidosis (Sphingomyelinase Deficiency)
Feline 3-6 months 3-6 months Stunted growth, ataxia, dysmetria, tremors; CNS, liver, lung, spleen, lymph
Siamese, DSH nodes, kidney, bone marrow, adrenal gland
Sphingomyelin in Lipidosis (Glucocerebrosidase Deficiency)
Canine 7 months 1 month CNS, liver
Sidney silkie
Mannosidosis (Alpha-Mannosidase Deficiency)
Neuronal Ceroid Lipofuscinosis Differentials, Lists, and Mnemonics
Canine 14-18 months 8-12 months Visual, mental, behavioral changes, cerebellar signs, seizures; CNS, lymph
English setters nodes, salivary gland, prostate, kidney
Leukodystrophies: Globoid Cell
Canine 11-30 weeks 2-3 months Tremor, dysmetria, paresis, muscle atrophy, visual changes, mental changes
Cairn and West Highland white terriers,
beagles, blue tick hound, poodles
Feline CNS, PNS
Metachromatic Leukodystrophy: Cavitating Leukodystrophy
Canine 3-6 months Decreased vision, ataxia, paresis
Dalmatians
CNS, Central nervous system; DSH, domestic shorthair; PNS, peripheral nervous system.
From Ettinger S, Feldman E: Textbook of veterinary internal medicine, ed 5, St. Louis, 2000, Saunders.

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