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1460 Drug Formulary Acetylcysteine (Mucomyst, N-acetylcysteine, NAC, ACC)

Drug Formulary
VetBooks.ir The drugs listed in this formulary represent a compilation of many of details of individual drugs is too voluminous to be listed in this format.

Therefore, it remains the clinician’s responsibility to ensure that the
the therapeutic agents used in small animal practice, without implying
endorsement (or lack thereof) of specific medications. Not all drugs particulars of any drug are appropriate for the intended application. The
used in veterinary practice are included, and some of those listed may be clinician should recheck drug dosages for accuracy as well as for specific
used infrequently. Drugs are organized in alphabetical order by generic indications, contraindications, and warnings. Again, the clinician needs
names, with trade names or often used synonyms in parentheses. The to identify the specific and recommended indications for each drug by
web version of the text also includes a cross-reference with many of reviewing relevant information (e.g., product insert, primary sources)
the trade names/synonyms listed alphabetically. We hope that this can before prescribing, recommending, or using a drug.
help you to find the drug of interest on those occasions in which the Although limitations of space do not allow inclusion in print, we encour-
brand name (e.g., Prozac) is commonly used and the generic name (e.g., age readers to avail themselves of additional drug-related information found
fluoxetine) just does not come readily to mind. Abbreviations used in in the web version of this text. This includes information regarding important
the formulary are first defined on this page for the reader’s reference. interactions between veterinary drugs, drugs of concern when administered
Canine and feline dosages are listed separately in the second and third to dogs with MDR1/ABCB1-Δ, charts comparing composition of fluid
columns, respectively. (The unit of measure of micron, sometimes denoted types, relative potency of various preparations of glucocorticoids, and more.
by the Greek letter μ, is abbreviated in this text by mc. For example, 1 mcL Materials presented are taken from several sources: 1) drug-related informa-
= 1 microliter; 1 mcg = 1 microgram.) The fourth column, titled Adverse tion from the other sections of this textbook; 2) the clinical experience of the
Effects/Warnings, describes important side effects or contraindications editors and previous redactors of this formulary; 3) Plumb DC: Veterinary
for each drug. A fifth column, titled Administration/Availability, includes Drug Handbook, ed 9, Ames, IA, 2018, Wiley; 4) Papich MG: Saunders
formulations and important notes about administration. This column Handbook of Veterinary Drugs: Small and Large Animal, ed 3, St. Louis,
also denotes the Controlled Substance Schedules (CSS) as listed by the 2011; 5) Ramsey I: BSAVA Formulary, Part A: Canine and Feline, ed 9, 2017,
U.S. Drug Enforcement Administration. Wiley; 6) VIN Veterinary Drug Handbook, www.vin.com. The editors thank
While every effort has been made to include clinically useful, Drs. Steve Ettinger and Wayne Schwark for their important contributions
important, and accurate information, a comprehensive review of the to the original version of this Formulary in the first edition of this textbook.

ABBREVIATIONS
AAFP: American Association of Feline Practitioners KCS: keratoconjunctivitis sicca
BSA: body surface area LDDST: low-dose dexamethasone suppression test
BW: body weight MAO: monamine oxidase
CHF: congestive heart failure mcg: microgram
CNS: central nervous system mcL: microliter
CRI: constant rate infusion MDR1/ABCB1-Δ: genetic mutation of P-glycoprotein
CSS: controlled substance schedule MUE: meningitis encephalitis of unknown etiology
D 5 W: sterile 5% dextrose in water NIOSH: National Institute for Occupational Safety and Health
DCM: dilated cardiomyopathy NSAIDs: nonsteroidal antiinflammatory drugs
DKA: diabetic ketoacidosis OA: affected eye
DM: diabetes mellitus OTC: over-the-counter
FDA: Food and Drug Administration PCV: packed cell volume
GI: gastrointestinal PO: per os (oral)
h: hour(s) prn: as needed
HDDST: high-dose dexamethasone suppression test PU/PD: polyuria/polydipsia
IBD: inflammatory bowel disease q: every
IM: intramuscular SQ: subcutaneous
IV: intravenous SVT: supraventricular tachycardia
IVDD: intervertebral disc disease U: unit(s)
A

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
Acarbose (Precose) Hypoglycemic agent: Hypoglycemic agent: Flatulence, diarrhea common. Tablets. Give with food.
12.5-25 mg/DOG orally q 12h 12.5 mg/CAT orally with each May contribute to episodes of
with each meal. Can increase meal q 12h. Can increase hypoglycemia.
dose to 50 mg/DOG q 12h. dose to 25 mg/CAT q 12h.
Acetylcysteine (Mucomyst, Hepatoprotection/antidote: Hepatoprotection: Dilute 10% Sulfurlike odor, bronchospasm Tablets, solutions for
N-acetylcysteine, NAC, Dilute 10% sterile NAC with sterile NAC with sterile saline if inhaled, GI distress for oral inhalation. Solutions
ACC) sterile saline 1 : 4; administer 1 : 4; administer 140 mg/kg IV routes. must be sterilized with a
140 mg/kg IV over 20 minutes, over 20 minutes, then 70 mg/ 0.22-micron filter before
then 70 mg/kg IV q 6h kg IV q 12h injection or use in the
Degenerative myelopathy: 25 mg/ eye. Dilute 10% solutions
kg PO q 8h for 2 weeks, then q 1 : 4 with saline before IV
8h q other day given concurrently administration.
with aminocaproic acid
Corneal ulceration: 2%-6%
solution topically q 2h for 24
hours, then q 6-8h for 1 week
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