Page 2799 - Cote clinical veterinary advisor dogs and cats 4th

1462 Amantadine (Symmetrel) Amitriptyline HCl (Elavil)

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
VetBooks.ir Amantadine (Symmetrel) Adjunct analgesia: 2-5 mg/kg Adjunct analgesia: 2–5 mg/kg GI upset occurs commonly in Tablets, capsules, syrup
dogs at onset of treatment. Use
PO once q 24h
PO q 24h
with caution in patients with
hepatic disease, renal disease
(dosage adjustment may be
required), CHF, active psychoses,
eczematoid dermatitis, or seizure
disorders.
Amikacin sulfate (Amikin, Susceptible infections: Susceptible infections: Adverse effects include Injection. For intravenous
Amiglyde-V) 15-30 mg/kg IV, IM, or SQ 10-15 mg/kg IV, IM, or SQ nephrotoxicity, ototoxicity, administration, should
q 24h q 24h neuromuscular blockade; these be further diluted with
adverse effects may be worse normal saline or D 5W and
in cats. Use carefully (if at administered over 30-60
all) in animals that have renal minutes.
insufficiency or are dehydrated.
Dose reduction has been
suggested for sighthounds.
Amino acids 3% and Partial parenteral nutrition: Partial parenteral nutrition: Thrombophlebitis, fever, and GI No longer commercially
glycerin injection with Maintenance rate Maintenance rate signs are potential complications. available. Pure amino
electrolytes (ProcalAmine) Hepatocutaneous syndrome: acid injections (8.5%,
25 mL/kg IV over 8 hours 10%) are still available.
Aminocaproic acid (Amicar) Antifibrinolytic: 50-100 mg/kg Use is not described in cats May cause GI upset in dogs Tablets (expensive),
PO, IV q 6-8h. May also be initially. Contraindicated in dogs injection. The injectable
used as prophylaxis prior to with active clotting disorders, formulation may be
surgery in sighthound breeds. including disseminated mixed with vitamin
Degenerative myelopathy: intravascular coagulation. solutions and given orally.
500 mg PO q 8h given Injectable formulations
concurrently with acetylcysteine can also be diluted in
0.9% saline for infusion
over 30 minutes.
Aminophylline Bronchodilator: 5-10 mg/kg Bronchodilator: 4-5 mg/kg PO CNS stimulation and GI upset Tablets are no longer
PO q 8-24h; can be given q 8-24h commercially available,
IM or diluted for slow IV though compounding
administration for emergent pharmacists may prepare
bronchodilation oral capsules from the
powder. The injectable
formulation may be given
orally followed by at least
6 mL of water or food.
Amiodarone (Cordarone, Arrhythmias: Initial loading Use in cats is not described. GI upset is common. Corneal Tablets, injection. Some
Pacerone) dosage of 8-10 mg/kg PO deposits, neutropenia, brands of intravenous
q 12h for 1 week and then thrombocytopenia, bradycardia, products may cause
reduced to 5-10 mg/kg PO q hepatotoxicity, and positive serious histamine
24h thereafter Coombs’ tests have also been reaction in dogs.
reported.
Amitraz (Mitaban) Demodicosis: Dilute 10.6 mL Do not use on cats. Transient sedation, skin irritation Solution for dipping. Also
per 2 gallons of water, and are possible. Ingestion can found in some tick collars
apply topically q 14 days for cause salivation, vomiting, for dogs.
3-6 treatments until mites are hyperglycemia, bradycardia,
gone. Wet coat thoroughly and and respiratory depression.
allow to air-dry. HIGHLY TOXIC to cats. MAO
inhibitor activity. Do not use with
interacting drugs (e.g., TCAs,
SSRIs, selegiline).
Amitriptyline HCl (Elavil) Adjunctive therapy for behavioral Anxiolytic for lower urinary Anticholinergic side effects are Tablets
disorders: 1-2 mg/kg PO q 12h tract syndrome: 5-10 mg/CAT common. Do not use with
Adjunctive analgesic therapy: (0.5-1 mg/kg) PO q 24h (can MAO inhibitors (e.g., amitraz).
3-4 mg/kg PO q 12h be divided twice daily) Use with caution in patients
with thyroid disorders, urinary
retention, hepatic disorders,
KCS, glaucoma, cardiac rhythm
disorders, DM, or adrenal tumors
due to anticholinergic adverse
effects.

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