Page 2803 - Cote clinical veterinary advisor dogs and cats 4th

1466 Buprenorphine HCl (Buprenex, Simbadol) Calcium Disodium EDTA (Calcium Disodium Versenate)

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
VetBooks.ir Buprenorphine HCl Analgesia: 5-40 mcg/kg Postoperative analgesia with Respiratory depression is the most likely Injection and extended-release
injection on FDA’s Index of
(0.005-0.04 mg/kg) IV, IM,
(Buprenex, Simbadol)
adverse effect, and vomiting and
Simbadol: 0.24 mg/kg SQ
q 24h up to 3 days
Legally Marketed Unapproved
behavioral changes can occur in dogs
or SQ q 6-12h
Analgesia: 10-30 mcg/kg
Species. CSS-III.
hypothermia, miosis, tachycardia, and
(0.01-0.03 mg/kg) IM, or cats. In dogs, salivation, bradycardia, New Animal Drugs for Minor
IV, or oral transmucosal high blood pressure have been reported.
q 6-8h In cats, mydriasis and hyperthermia have
been reported.
Buspirone (BuSpar) Behavioral disorders: Behavioral disorders: Generally, well tolerated but bradycardia, Tablets
0.5-2 mg/kg PO q 8-12h 0.5-1 mg/kg (or GI disturbances, and stereotypic
2.5 mg/CAT) PO q 8-12h behaviors have been reported.
Undesirable behavioral changes may
result from disinhibition.
Busulfan (Myleran, Busulfex) Antineoplastic: 3-4 mg/m 2 Antineoplastic: 2-4 mg/m 2 Myelosuppression is common and Tablets. Cytotoxic, NIOSH-listed
PO q 24h PO q 24h potentially severe. Pulmonary fibrosis, hazardous drug and should
hepatotoxicity, and hyperpigmentation of be prepared, administered,
skin may occur. Uric acid levels should and disposed of in
be monitored. accordance with federal and
local requirements.
Butorphanol tartrate (Stadol, Analgesia, sedation: 0.2-1 mg/ Analgesia: 0.1-0.5 mg/kg q Reduce dose in dogs with MDR1/ABCB1-Δ Tablets, injection. CSS-IV.
Torbutrol, Torbugesic) kg PO, IM, SQ q 6-12h; 6-12h IV, IM, SQ mutation. Potential adverse effects
0.1-0.2 mg/kg IV. At dose of include sedation, ataxia, anorexia,
0.1-0.5 mg/kg IV, IM can be vomiting, or diarrhea (rarely).
combined with acepromazine
0.025-0.05 mg/kg mixed in
same syringe
Antitussive: 0.5-1 mg/kg PO
q 6-12h
C

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
Cabergoline (Dostinex, Prolactin inhibition: 5 mcg/kg Prolactin inhibition: Vomiting is the most common Available only through
Galastop) (0.005 mg/kg) PO q 8h 25-50 mcg/CAT or adverse effect. Has caused compounding in the United
5-10 mcg/kg PO q 24h changes in coat color. States; oral solution available
in Europe.
Calcitonin (Miacalcin, Hypercalcemia of malignancy: Hypercalcemia of malignancy: Anorexia and vomiting are the most Injection, metered-dose inhaler.
Calcimar) 4-8 units/kg IV, IM, or SQ q 12h 4-8 units/kg IV, IM, or SQ common adverse effects. Pain at Expensive.
q 12h injection site is also reported.
Calcitriol (Rocaltrol, Calcijex) Hypoparathyroidism: 0.03- CKD: Initial dosage 1.65- May cause hypercalcemia or Capsules, oral solution, and
0.06 mcg/kg PO q 24h, then 3.63 ng/kg (= 0.00165- hyperphosphatemia (monitor injection. A dilute solution
0.005-0.015 mcg/kg PO q 24h, 0.00363 mcg/kg) PO q 24h levels closely). may be prepared from the
with oral calcium and adjusted on empty stomach, adjusted concentrated oral solution to
prn upward prn better achieve small doses.
CKD: 2-2.5 ng/kg PO q 24h Oil can be removed from
on empty stomach, adjusted capsule and diluted in corn oil
upward prn not to exceed 7 ng/ and stored for up to 2 weeks.
kg/d, or pulse dose of 20 ng/
kg twice weekly at bedtime on
empty stomach
Calcium carbonate (Tums, Calcium supplementation/ Calcium supplementation/ Hypercalcemia is possible with Tablets OTC, powder (Epakitin).
Epakitin) phosphate binder: 90-150 mg/ phosphate binder: overdosing or prolonged dosing. Administer 1 hour before or 2
kg/d PO divided and given with 90-150 mg/kg/d PO divided Interacts with many drugs and hours after other medications.
food or just before each meal and given with food or just must be given 1 hour before or
Epakitin phosphorous binder: before each meal 2 hours after other drugs.
1 g/5 kg BW PO q 12h with Epakitin phosphorous binder:
food 1 g/5 kg BW PO q 12h with
food
Calcium Disodium EDTA Heavy metal poisoning: 25 mg/kg Heavy metal poisoning: Painful on IM injection. Do not Available only through
(Calcium Disodium SQ q 6h diluted in 5% dextrose 27.5 mg/kg SQ in 15 mL confuse with Sodium EDTA. compounding. Dilute to
Versenate) for 2-5 days 5% dextrose q 6h for 5 days; 10 mg/mL in D 5 W before
rest for 5 days, repeat if administration.
needed

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