Page 2806 - Cote clinical veterinary advisor dogs and cats 4th

Cimetidine (Tagamet) Clomipramine (Clomicalm, Anafranil) 1469

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
VetBooks.ir Cimetidine (Tagamet) H 2 blocking antacid: 5-10 mg/kg H 2 blocking antacid: 2.5-5 mg/ Multiple drug interactions and Tablets, oral solution (both
PO or IV q 6-8h
limited efficacy mean that this
kg PO q 6-12h
OTC), and injection
drug is now rarely used in dogs
or cats.
Ciprofloxacin (Cipro) Susceptible infections: 25-30 mg/ Susceptible infections: Well tolerated but can cause Tablets (crush before
kg PO q 24h, or 20-25 mg/kg 20-25 mg/kg PO q 24h, or GI distress, CNS stimulation, administration), injection, and
IV q 24h 20-25 mg/kg IV q 24h crystalluria, urolithiasis, and ophthalmic preparations
hypersensitivity. Intact tablets
have variable bioavailability
in dogs, but using higher
dosage and crushing tablets
often permits therapeutically
effective blood levels. Like other
fluoroquinolones, it is relatively
contraindicated for young,
growing animals due to cartilage
abnormalities. Use with caution
in hepatic or renal insufficiency,
dehydration.
Cisapride Prokinetic: 0.5 mg/kg PO q Prokinetic: 2.5 mg/CAT PO Generally well tolerated in Available only through
8-12h; can gradually increase to q 12h initially, gradually animals but GI upset can occur. compounding
1 mg/kg PO q 8h increasing up to 7.5 mg/CAT Contraindicated in GI obstruction.
q 8h if needed. Often Discontinued for human use due
combined with lactulose for to QT interval prolongation.
treatment of constipation.
Cisplatin (Platinol-AQ) Antineoplastic: 50-70 mg/m 2 Do not use in cats. Never use in cats due to risk of Injection for infusion; must be
slow IV infusion q 3-5 weeks fatal pulmonary edema. Adverse given as slow IV infusion to
accompanied with saline effects in dogs include GI upset, dogs with fluid diuresis before
diuresis nephrotoxicity, ototoxicity, and and after infusion. Cytotoxic,
Intrapleural instillation: 50 mg/ myelosuppression. NIOSH-listed hazardous drug
m diluted in saline to volume and should be prepared,
2
of 250 mL/m , warmed to body administered, and disposed
2
temperature, and infused into of in accordance with federal
pleural space q 3-4 weeks prn and local requirements.
to control malignant effusion
Clarithromycin (Biaxin) Susceptible infections: 5-12.5 mg/ Susceptible infections: 7.5 mg/ Generally well tolerated other than Tablets, oral suspension
kg PO q 12h kg or 62.5 mg/CAT PO q 12h GI upset. Many drug interactions.
Clindamycin (Antirobe, Susceptible infections: 11-33 mg/ Susceptible infections including Adverse effects include GI upset or Tablets, capsules, oral solution,
Cleocin) kg PO q 12h; 10-15 mg/kg IV toxoplasmosis: 11-33 mg/kg esophageal injuries (esophagitis, powder, topical solutions, and
q 12h PO q 24h strictures) when solid dosage injection
forms were given without food
or a water bolus. Cats may show
hypersalivation or lip smacking
after administration of the oral
liquid due to the unpleasant
taste.
Clofazimine (Lamprene) M. avium-intracellulare complex M. avium-intracellulare Adverse effects are usually GI Tablets. May be difficult for
infections, or opportunistic complex infections, feline upset (may be dose-limiting). veterinarians to obtain due
mycobacteriosis: 4-8 mg/kg PO leprosy, or opportunistic Clofazimine stains skin, eyes, to restricted distribution
q 24h for 4 weeks, usually as mycobacteriosis: 4-10 mg/ bodily fluids, and excreta. systems.
part of a multidrug protocol kg, or 25-50 mg/CAT PO Treatment duration often for
q 24-48h for 4 weeks, weeks to months.
usually as part of a multidrug
protocol
Clomipramine (Clomicalm, Behavior modification: 1-2 mg/kg Behavior modification: Avoid use in animals exposed to Tablets
Anafranil) PO q 12h initially and eventually 0.25-1 mg/kg PO q 24h; MAO inhibitors (e.g., amitraz
up to 3 mg/kg PO q 12-24h begin at lower dose and and l-deprenyl). Adverse effects
titrate up prn include GI upset, sedation,
anticholinergic effects; cats
may be more sensitive than
dogs. Use with caution in liver
disease, cardiac rate and rhythm
disorders, urinary retention, or
Drug Compendium
reduced GI motility. Avoid use in
breeding males.

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