Page 2808 - Cote clinical veterinary advisor dogs and cats 4th

Cyproheptadine (Periactin) Darbepoetin (Aranesp) 1471

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
VetBooks.ir Cyproheptadine (Periactin) Dysphoria of serotonin syndrome Appetite stimulant: 1-4 mg/CAT Agents such as capromorelin (for Tablets, oral solution
or toxicoses: 1.1 mg/kg PO;
dogs) and mirtazapine (for dogs
PO q 8-25h (largely obsolete
use)
and cats) have made use of
doses may be repeated q 4-6h
as needed until signs have
syndrome or toxicoses:
stimulant obsolete. Use of
resolved Dysphoria of serotonin cyproheptadine as an appetite
Appetite stimulation: 0.2 mg/kg 2-4 mg/CAT PO; doses cyproheptadine in small animals
PO q 12h may be repeated q 4-6h as an antihistamine is becoming
as needed until signs have rare. Adverse effects include
resolved sedation and anticholinergic
effects. Cats may exhibit
paradoxical hyperstimulation;
some reports of hemolytic
anemia in cats.
2
Cytarabine (Cytosar-U) Antineoplastic: 300 mg/m SQ Antineoplastic: 100 mg/m SQ Adverse effects are primarily GI Injection. Cytotoxic, NIOSH-
2
divided into 3 or 4 doses q q 12h for 2 to 4 days. Use in and myelosuppression. listed hazardous drug
24h over 3-4 days, or IV as a cats is not well-described. and should be prepared,
continuous infusion (lasting 4-8 administered, and disposed
hours) once weekly of in accordance with federal
Inflammatory brain disease (MUE): and local requirements.
50 mg/m SQ q 12h for 2
2
consecutive days, or 25 mg/m 2
per hour for an 8-hour CRI; may
be repeated q 3-4 weeks
D

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
2
Dacarbazine (DTIC) Antineoplastic: 800-1000 mg/m Do not use in cats. Adverse effects include GI toxicity and Injection. Cytotoxic,
IV over 4-8 hours q 2-3 weeks myelosuppression. Usually reserved NIOSH-listed hazardous
OR lower dosage 200-250 mg/ for cases not responsive to more drug and should be
2
m q 24h IV for 5 days with conventional therapies. prepared, administered, and
the treatment cycle repeated q disposed of in accordance
3-4 weeks with federal and local
requirements.
2
Dactinomycin (Cosmegen, Antineoplastic: 0.5-1 mg/m IV Dosing is not described for Adverse effects are primarily GI toxicity Injection. Cytotoxic,
actinomycin-D) over 20 minutes; repeated at cats. and myelosuppression. NIOSH-listed hazardous
1- to 3-week intervals drug and should be
prepared, administered, and
disposed of in accordance
with federal and local
requirements.
Dalteparin (Fragmin, LMWH) Thromboprophylaxis: Thromboprophylaxis: Can cause or worsen bleeding; Injection (expensive). U-100
100-150 units/kg SQ q 8-12h No consensus dosing contraindicated with severe insulin syringes useful for
described, but thrombocytopenia. Available in broad providing accurate dosing.
100-175 units/kg SQ q range of concentrations; ensure
6-12h described correct dosing.
Dapsone (Avlosulfon) Mycobacteriosis: 1.1. mg/kg Do not use in cats. Due to its adverse effect profile Tablets
PO q 6h until remission, then (hepatotoxicity, dose-dependent
0.3 mg/kg q 8-12h methemoglobinemia, hemolytic
Spider envenomation: 1 mg/kg anemia, thrombocytopenia,
PO q 24h for 10 days (inhibits neutropenia, GI effects, cutaneous
neutrophil migration) drug eruptions, and neuropathies),
dapsone is rarely used in veterinary
medicine. Dapsone is a potential
carcinogen.
Darbepoetin (Aranesp) Erythropoiesis: 0.45-1.5 mcg/ Erythropoiesis: 0.7-1.8 mcg/ Anti-erythropoietin antibody formation Injection
kg SQ once weekly until the kg SQ once weekly until with resultant pure red blood cell
target PCV is attained, then the target PCV is attained, aplasia (PRCA) may occur as well as
extending interdose interval as then extending interdose injection-site reactions, polycythemia, Drug Compendium
tolerated (q 2-3 weeks typical). interval as tolerated (q 2-3 hypertension, seizures, or iron
Administer iron supplement. weeks typical). Administer deficiency.
iron supplement.

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