Page 2812 - Cote clinical veterinary advisor dogs and cats 4th

DL-methionine Doxorubicin (Adriamycin, Doxil) 1475

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
VetBooks.ir DL-methionine Urinary acidification: 100 mg/kg Urinary acidification: Adverse effects include GI distress (food Tablets, powder, gel; give
1000-1500 mg/CAT PO
with food
PO q 12h
may alleviate), Heinz-body hemolytic
anemia (cats). Contraindicated in
q 24h
renal failure, pancreatic disease,
hepatic insufficiency, pre-existing
acidosis, oxalate or urate calculi.
Dobutamine HCl (Dobutrex) Hypotension (after volume Hypotension (after volume Use for no longer than 48 hours; may Injection
resuscitation): CRI IV of resuscitation): CRI IV increase heart rate—monitor for
2.5-20 mcg/kg/min titrated of 2.5-20 mcg/kg/min arrhythmias; cats are very sensitive to
upward to effect in sterile LRS, titrated upward to effect dobutamine and may have seizures;
0.9% NaCl or D 5W in sterile LRS, 0.9% NaCl doses >10 mcg/kg/min in dogs are
or D 5W more likely to be arrhythmogenic.
Dopamine HCl (Intropin) Hypotension (after volume Hypotension (after volume GI upset, arrhythmia, hypotension Injection
resuscitation): CRI IV of resuscitation): CRI IV of or hypertension, dyspnea,
2-2.5 mcg/kg/min titrated 2-2.5 mcg/kg/min titrated and vasoconstriction can
upward to effect, often in upward to effect, often in occur. Contraindicated in
7-15 mcg/kg/min range 7-15 mcg/kg/min range pheochromocytoma, ventricular
fibrillation, and uncorrected
tachyarrhythmia. Extravasation can
cause severe tissue damage.
Doramectin (Dectomax) Demodectic and sarcoptic Demodicosis: 400-600 mcg/ Contraindicated in dogs with the MDR1/ Injection
mange: 0.6 mg/kg PO or SQ kg (0.4-0.6 mg/kg) SQ q ABCB1-Δ genetic mutation. Adverse
q 7 days; continue treatment 7 days for 4 weeks past 2 effects are rare in nonmutant dogs,
until remission of clinical signs consecutive negative skin but include pupil dilation, lethargy,
and no evidence of mites on scrapings 4-6 weeks apart blindness, or coma.
2 successive skin scrapings
14 days apart; 0.3 mg/kg
SQ q 3-4 days may be better
tolerated than 0.6 mg/kg q
7 days
Dorzolamide (Trusopt) Glaucoma: 1 drop OA q 8-12h Glaucoma: 1 drop OA q Adverse effects include burning and Ophthalmic solution,
8-12h stinging upon application (due to low sometimes combined with
pH), superficial punctate keratitis, timolol
local hypersensitivity reactions, and
corneal edema.
Doxapram (Dopram-V) Laryngeal function exam: 2.2 mg/ Laryngeal function exam: Adverse effects include hypertension, Injection
kg IV 2.2 mg/kg IV arrhythmias, seizures,
Stimulate respiration during Stimulate respiration during hypersensitivity, and respiratory
anesthesia: 1.1 mg/kg (with anesthesia: 1.1 mg/ alkalosis. Contraindicated in
gas anesthesia) or 5.5-11 mg/ kg (with gas anesthesia) mechanical ventilation, seizure
kg (with barbiturate anesthesia) or 5.5-11 mg/kg (with disorders, head trauma, respiratory
IV barbiturate anesthesia) IV failure secondary to neuromuscular
Stimulate respiration in neonates: Stimulate respiration in disorders, airway obstruction,
0.1 mL (2 mg) IV in umbilical neonates: 0.1 mL (2 mg) pulmonary embolism, pneumothorax,
vein (IM or sublingual also IV in umbilical vein (IM or acute asthma, dyspnea, or whenever
possible) sublingual also possible) hypoxia is not associated with
hypercapnia.
Doxepin (Sinequan) Psychogenic dermatoses: Psychogenic dermatoses: Contraindicated in animals currently or Tablets, capsules, oral solution
3-5 mg/kg (not more than 0.5-1 mg/kg PO q 12-24h recently (within 2 weeks) exposed to
50 mg/DOG) PO q 12h tapered tapered to lowest effective MAO inhibitors or fluoxetine. Adverse
to lowest effective dose dose effects include hyperexcitability,
GI distress, or lethargy, and a
dose-related ventricular tachycardia.
2
Doxorubicin (Adriamycin, Antineoplastic: 30 mg/m IV Antineoplastic: 20-25 mg/ Adverse effects include Injection administered by IV
Doxil) q 2-3 weeks. Maximum m or 1 mg/kg IV q myelosuppression, cardiac toxicity catheter with 0.9% saline or
2
cumulative dose = 3-5 weeks. Maximum (dogs), nephrotoxicity (cats), alopecia, 5% dextrose infusion over
2
180-240 mg/m depending on cumulative dose suggested gastroenteritis (vomiting, diarrhea), ≥15 minutes. Cytotoxic,
breed and risk factors. 180 mg/m . 2 and stomatitis. Some brands cause NIOSH-listed hazardous
hypersensitivity in dogs. Use with drug and should be
caution in patients with impaired prepared, administered, and
hepatic function (dosage adjustments disposed of in accordance
necessary), and in dogs with MDR1/ with federal and local
ABCB1-Δ mutations. Extravasation requirements. Extravasations
Drug Compendium
can cause severe tissue damage should be treated with
(dexrazoxane treatment indicated). dexrazoxane.

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