Page 2817 - Cote clinical veterinary advisor dogs and cats 4th

1480 Fluorouracil (Adrucil, 5-FU) Furosemide

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
VetBooks.ir Fluorouracil (Adrucil, 5-FU) Antineoplastic: 150 mg/m IV Do not use in cats. Contraindicated in poor nutritional Injection, topical cream.
2
Cytotoxic, NIOSH-listed
weekly, or 5-10 mg/kg IV
states, with bone marrow suppression,
or with serious infections. Adverse
hazardous drug and
weekly
effects include dose-dependent
myelosuppression, GI toxicity, and should be prepared,
administered, and
neurotoxicity. disposed of in
accordance with
federal and local
requirements.
Fluoxetine (Prozac, Behavioral disorders: 1-2 mg/kg Behavioral disorders: Do not use in patients receiving MAO Tablets, oral solution
Reconcile) PO q 24h 0.5-1 mg/kg or 2 mg/CAT inhibitors (e.g., amitraz, l-deprenyl).
PO q 24h Use with caution in DM or seizure
disorders; dosages may need to be
reduced in patients with severe
hepatic impairment. Adverse effects
include anorexia, lethargy, GI
effects, anxiety, irritability,
insomnia, hyperactivity, panting,
or hyperreactivity.
Flurbiprofen (Ocufen) Ocular NSAID: 1 drop in affected Ocular NSAID: 1 drop in Minor ocular irritation or discomfort, Ophthalmic solution
eye q 6-24h affected eye q 6-24h miosis, or mydriasis can be seen.
Contraindicated in hypersensitivity.
Fluticasone (Flovent, Glucocorticoid for inflammatory Glucocorticoid for inflammatory Well tolerated, although HPA axis Metered-dose inhaler in
Flixotide) airway disease: 1 puff (110 airway disease: 1 puff suppression is possible. Demodicosis three strengths. Use
or 220 mcg/puff strength) q (usually 110 mcg/puff has been reported in contact areas on with appropriate face
12-24h using an appropriate strength, but some prefer muzzle. mask and spacer device,
spacer and mask 220 mcg/puff) q 12-24h allowing 10 breaths
using an appropriate spacer after actuation. Also
and mask available as intranasal
spray, ointments, and
topical creams, or in
combination with other
drugs (e.g., salmeterol)
for inhalational
administration.
Folic acid (folate, vitamin Folate deficiency: 1-5 mg PO, Folate deficiency: 1-5 mg PO, Very well tolerated Tablets OTC, injection
B 9) SQ weekly SQ weekly
Poorly regenerative anemia: Supplement during prolonged
1-5 mg PO q 24h (anecdotal) trimethoprim/sulfa treatment:
2 mg/CAT q 24h
Fomepizole (Antizol-Vet, Ethylene glycol poisoning: 20 mg/ Ethylene glycol poisoning: Adverse effects after rapid IV infusion Injection. Veterinary
4-MP) kg IV, then 15 mg/kg IV 12 125 mg/kg slow IV, then include phlebitis and phlebosclerosis; product discontinued
and 24 hours later, then final 31.25 mg/kg IV at 12, 24, anaphylaxis is possible. Monitor and and human product
dose of 5 mg/kg 36 hours after and 36 hours. Cats must treat acid/base, fluid, and electrolyte very expensive. Dilute
initial dose; may give additional be treated within 3 hours of imbalances. May inhibit elimination of with saline or D 5 W and
5 mg/kg doses as necessary ingestion. ethanol (and vice versa). administer by slow IV
infusion.
Fondaparinux (Arixtra) Use not described for dogs. Anticoagulant; Selectively binds antithrombin, inactivating Injection
thromboprophylaxis: factor Xa. No effect on platelet function.
0.06 mg/kg SQ q 12h No clinical trials to establish safety
or efficacy in cats at this time, but
bleeding is a potential complication
of use.
Furosemide Loop diuretic: Initial 2 mg/kg q Loop diuretic: Initially 1 mg/kg Electrolyte depletion; dehydration; may Injection, tablets, syrup.
8-12h IV, IM, SQ, or PO. Can IV, IM, SQ, or PO q 8-24h; increase toxicity of other drugs (e.g., Tablets can be split.
increase dose or frequency if may increase if needed up amphotericin B, aminoglycosides, ACE Check pH of various
needed in treatment of CHF up to 4 mg/kg. Titrate to lowest inhibitors, glucocorticoids) products before
to 6 mg/kg. Alternatively, initial effective dose/frequency for administering SQ.
bolus followed by 0.1-1 mg/ chronic use. Human-labeled products
kg/h CRI. Titrate to lowest have a pH of 8-9.3
effective dose/frequency for and are painful on SQ
chronic use. injection.

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