Page 2820 - Cote clinical veterinary advisor dogs and cats 4th

Hydralazine (Apresoline) Hydromorphone (Dilaudid) 1483

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
VetBooks.ir Hydralazine (Apresoline) CHF due to valvular disease: Vasodilation in CHF: Adverse effects include hypotension, Tablets, injection
2.5 mg/CAT PO q 12h,
reflex tachycardia, sodium/water
0.5-3 mg/kg PO q 12h,
retention (if not given concurrently
titrating from lowest dose prn
titrated prn to a maximum of
with a diuretic), or GI upset
10 mg/CAT q 12h
(common). Use with caution in
dogs receiving ACE inhibitors, with
severe renal disease, intracerebral
bleeding, or pre-existing autoimmune
diseases. Contraindicated with
hypovolemia or pre-existing
hypotension.
Hydrochlorothiazide Systemic hypertension: 1 mg/ CHF refractory to furosemide GI upset, hypokalemia, hypochloremic Tablets and capsules,
(HydroDIURIL, Microzide, kg PO q 12-24h (may alone: 1-2 mg/kg PO q 12h alkalosis, and other electrolyte and in combination with
HCTZ) combine with spironolactone Prevention of oxalate uroliths: imbalances can occur. Ensure that spironolactone.
1-2 mg/kg PO q 12h to 1 mg/kg PO q 12h tablets do not contain spironolactone
reduce potassium loss) Diabetes insipidus: when treating cats. Contraindicated
Malignancy-associated 12.5-25 mg/CAT PO q in pregnancy. Avoid with severe
hypoglycemia: 2-4 mg/kg 12-24h renal disease, pre-existing electrolyte
PO q 24h in conjunction with and water balance abnormalities,
diazoxide 5-20 mg/kg q 12h impaired hepatic function,
Prevention of calcium oxalate hyperuricemia, systemic lupus, or
uroliths: 2-3 mg/kg PO q diabetes mellitus. Multiple drug
12h interactions.
Diabetes insipidus: 2 mg/kg
PO q 12h
Hydrocodone bitartrate Antitussive: 0.2-0.5 mg/kg PO Rarely used in cats. Many Adverse effects include sedation, Tablets and oral solutions;
(Tussigon, Hycodan) q 6-12h products also contain constipation (with chronic therapy), often combined with
acetaminophen. vomiting, or other GI disturbances. acetaminophen. CSS-II.
Contraindicated in patients receiving
MAO inhibitors (e.g., amitraz
and l-deprenyl), and in patients
with diarrhea caused by a toxic
ingestion. Any combination product
containing acetaminophen must NOT
be used in cats. Use with caution
in hypothyroidism, severe renal
insufficiency, hypoadrenocorticism,
increased intracranial pressure,
acute abdominal conditions, and
geriatric or severely debilitated
patients.
Hydrocortisone acetate Glucocorticoid. Glucocorticoid. Adverse effects are those associated Tablets, injection, and topical
(Cortef, Solu-Cortef) Hypoadrenocorticism: Hypoadrenocorticism: with glucocorticoid use (e.g., PU/PD). creams (some OTC). Often
0.4-0.8 mg/kg PO q 12-24h 0.4-0.8 mg/kg PO q 12-24h Oral forms may cause GI upset and compounded.
Post-CPR recovery: 1 mg/kg Post-CPR recovery: 1 mg/kg gastric ulceration.
IV followed by either 1 mg/ IV followed by either 1 mg/
kg q 6h IV or 0.15 mg/kg/h kg q 6h IV or 0.15 mg/kg/h
IV CRI, then tapered as the IV CRI, then tapered as the
patient’s condition allows patient’s condition allows
Hydrogen peroxide 3% (H 2 O 2 ) Emetic: 2.2 mL/kg PO, to a Do not use as an emetic in Emesis induction is not appropriate for Solution OTC
maximum of 45 mL/DOG; cats. all toxin ingestions and is often not
may repeat once in 15 helpful after onset of signs due to
minutes intoxication. Can cause esophageal
Topically: Used for wound or gastric irritation, and aspiration
cleaning is possible. Do not use in dogs with
severe lethargy, megaesophagus,
debilitation (e.g., respiratory distress,
decreased swallowing reflex,
bradycardia), seizures, or in dogs
that have had recent abdominal
surgery.
Hydromorphone (Dilaudid) Analgesia: 0.05-0.2 mg/kg IV, Analgesic: 0.05-0.1 mg/kg IV, Dogs: Nausea, vomiting, defecation, Injection. CSS-II.
IM, or SQ q 2-4h or given as IM, or SQ q 2-6h or given panting, vocalization, and sedation
a CRI with an initial dose of as a CRI at 0.01-0.05 mg/ are common; CNS and respiratory
0.05-0.1 mg/kg IV and then kg/h IV depression, bradycardia, decreased
as CRI at 0.01-0.05 mg/ GI motility possible.
kg/h IV Cats: Nausea, ataxia, hyperesthesia, Drug Compendium
hyperthermia (monitor temperature),
and behavioral changes.

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