Page 2819 - Cote clinical veterinary advisor dogs and cats 4th

1482 Gonadotropin-releasing hormone (GnRH, gonadorelin, Cystorelin) Hetastarch 6% (Hespan)

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
VetBooks.ir Gonadotropin-releasing Male infertility or test for Male infertility or test for Response may be clinical (overt Injection
cryptorchidism: 2.2-3.3 mcg/
physical signs) or endocrine
hormone (GnRH,
cryptorchidism: 25 mcg/CAT
(2- to 4-fold increase in serum
gonadorelin, Cystorelin)
kg IM
IM
testosterone levels).
Granisetron (Kytril) Antiemetic: 0.1-0.5 mg/kg PO or Antiemetic: 0.1-0.5 mg/kg PO Use in veterinary medicine is Tablets, injection, and
IV q 12-24h or IV q 12-24h uncommon due to availability transdermal patch
of other antiemetics such as
maropitant.
Grapiprant (Galliprant) Analgesia/antiinflammatory: Grapiprant is not labeled for Well tolerated but GI adverse effects Tablets
2 mg/kg PO q 24h (dose cats; however, 3-15 mg/ are possible from this prostaglandin
in 1 2 tablet increments kg PO q 24h for 28 days receptor antagonist. Avoid
according to label directions) appeared safe combination with glucocorticoids or
COX-inhibiting NSAIDs.
Griseofulvin (Fulvicin, Dermatophytosis (rarely used): Do not use in cats. Azole antifungals and terbinafine Microsize and ultramicrosize
Gris-Peg) microsize forms—50 mg/ have replaced griseofulvin for oral suspension; give with
kg PO q 24h or divided and use in treating dermatophytosis. a fatty meal.
given q 12h; ultramicrosize Ultramicrosize is 1.5 times more
forms—5-10 mg/kg PO q 24h potent than microsize. Contraindicated
in pregnancy, known hypersensitivity,
or hepatocellular failure. Known
teratogen in cats. Adverse effects
include anorexia, vomiting, diarrhea,
anemia, neutropenia, leukopenia,
thrombocytopenia, depression,
ataxia, hepatotoxicity, or dermatitis/
photosensitivity.
Growth hormone, human Hypopituitary dwarfism: 0.1 units/ Use is not described for cats. May cause DM; blood and urine Injection
(somatotropin) kg (0.05 mg/kg) SQ 3 times glucose should be monitored.
per week for 4-6 weeks Hypersensitivity reactions are
Alopecia X: 0.15 units/kg of possible, but less so if using porcine
porcine growth hormone SQ 2 origin product. Long-term use of
times weekly for 6 weeks high doses may cause acromegaly.

H

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
Heparin, unfractionated Anticoagulant dose adjusted Thromboprophylaxis: Can cause or worsen bleeding; Injection (variable
based on response, with 50-100 units/kg (low-dose) contraindicated in severe concentrations—check
usual goal of 1.5 to 2× or 200-300 units/kg thrombocytopenia. Protamine sulfate labels carefully)
increase in aPTT: Initial (high-dose) SQ q 6-8h may be used as antidote. Not
dose 150-300 units/kg SQ effective if antithrombin depleted.
q 6-8h, or loading dose of
100 units/kg IV followed by
20-50 units/kg/h IV CRI
Heparin, low-molecular-
weight: see dalteparin and
enoxaparin
Hetastarch 6% (Hespan) Colloid: 5-10 mL/kg IV bolus, Colloid: 10-15 mL/kg/d IV CRI Adverse effects include volume Solution for infusion
followed by 1 mL/kg/h IV CRI overload, disturbed coagulation,
allergic reaction, and possible
nephrotoxicity. Rapid administration
to cats can cause vomiting.

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