Page 2823 - Cote clinical veterinary advisor dogs and cats 4th

1486 Insulin, glargine (Lantus) Iron-dextran injection

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
VetBooks.ir Insulin, glargine (Lantus) DM: 0.3 units/kg q 12h, DM: 0.25 units/kg or 1 unit/CAT Hypoglycemia is most important Injection; use U100 syringes
adjusted prn. Not generally
for injection. Vial should be
adverse effect. Other adverse
q 12h, adjusted prn. A
rolled to mix and not shaken.
preferred insulin for cats.
effects include insulin-induced
recommended for dogs.
hyperglycemia (Somogyi effect),
insulin antagonism/resistance, Also available as insulin pen
(stored at controlled room
rapid insulin metabolism, and temperature after opening).
local hypersensitivity reactions. NOTE: Basaglar may not be
a therapeutic equivalent to
Lantus in cats.
Insulin, NPH (Humulin-N, DM: 0.25-0.5 units/kg SQ Rarely used for cats. Hypoglycemia is most important Injection; use U100 syringes
Novolin-N) q 12h, adjusted prn. A adverse effect. Other adverse for injection. Vial should be
preferred insulin for dogs. effects include insulin-induced rolled to mix and not shaken.
hyperglycemia (Somogyi effect),
insulin antagonism/resistance,
rapid insulin metabolism, and
local hypersensitivity reactions.
Insulin, lente (Vetsulin) DM: 0.25-0.5 units/kg SQ DM: 0.25-0.5 units/kg, or Hypoglycemia is most important Injection; use U40 insulin
q 12h, adjusted prn. A 1 unit/CAT SQ q 12h adverse effect. Other adverse syringes for injection. Unlike
preferred insulin for dogs. effects include insulin-induced other insulins, vial should
hyperglycemia (Somogyi effect), be well shaken to mix. Also
insulin antagonism/resistance, available with insulin pen.
rapid insulin metabolism, and
local hypersensitivity reactions.
Insulin, PZI (Prozinc) DM: 0.25-0.5 units/kg SQ DM: 1 unit/CAT SQ q 12h, Hypoglycemia is most important Injection; use U40 insulin
q 12h, adjusted prn. Not adjusted prn. A preferred adverse effect. Other adverse syringes for injection. Vial
generally recommended for insulin for cats. effects include insulin-induced should be rolled to mix and
dogs. hyperglycemia (Somogyi effect), not shaken.
insulin antagonism/resistance,
rapid insulin metabolism, and
local hypersensitivity reactions.
Interferon-alfa (huIFN-alfa Cutaneous or oral papillomas: Antiviral cytokine: 10 units/kg Oral dosing seems to be very well Injection; may be further
2
Intron-A) 1.5-2 million units/m SQ 3 PO q 24h, or 30-50 units/CAT, tolerated. Injectable high doses diluted in saline for SQ or
times weekly or 10,000 units/kg SQ q 24h; in cats may cause malaise, fever, oral use.
may be continued 1 week allergic reactions, myelotoxicity,
on treatment, one week off myalgia, and injection site
treatment. reactions. Use with caution in
pre-existing autoimmune disease,
severe cardiac disease, pulmonary
disease, uncontrolled DM, herpes
infections, hypersensitivity to the
drug, or CNS disorders.
Interferon-omega (Virbagen Antiviral cytokine (parvovirus): Antiviral cytokine (retrovirus): Well tolerated but GI upset and Injection. No approved product
Omega, Recombinant 2.5 million units/kg IV q 24h 1 million units/kg SQ q 24h post-treatment hyperthermia in the United States, but
Omega Interferon of for 3 days for 5 days, repeated again 2 have been reported. Intravenous available in European Union,
Feline Origin, weeks and 2 months later administration to cats may Asia. Expensive.
rFeIFN-ω, Virbagen) cause increased incidence and
severity of adverse effects. Do
not vaccinate animals currently
undergoing treatment. Dogs
may develop antibodies to this
recombinant feline product.
Expensive.
Irbesartan (Avapro) Hypertension: 5 mg/kg PO Hypertension: 5 mg/kg PO q Little known about use in veterinary Tablets; tablets with HCTZ
q 12h 12h patients. Adverse effects include
diarrhea, dyspepsia, fatigue,
orthostatic dizziness, and
hypotension.
Iron-dextran injection Iron supplementation: Iron supplementation: 10 mg/kg Causes pain on IM injection. Chronic Injection
10-20 mg/kg (maximum IM once monthly or converted overdosage can cause cirrhosis.
300 mg/DOG) IM once to oral ferrous sulfate Do not use in patients with acute
monthly or converted to oral pyelonephritis, and should not be
ferrous sulfate used in conjunction with oral iron
supplements.

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