Page 2824 - Cote clinical veterinary advisor dogs and cats 4th

Isoproterenol (Isoprenaline, Isuprel) Kaolin-pectin (Kaopectolin) 1487

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
VetBooks.ir Isoproterenol (Isoprenaline, Sinus bradycardia, complete Sinus bradycardia, complete Can cause tachycardia, anxiety, Injection. Dilute 1 mg into
AV block: 0.02-0.5 mcg/kg/
Isuprel)
tremors, and GI upset. More
500 mL of D 5W to make a
AV block: 0.02-0.5 mcg/kg/
min IV, or 0.04-0.08 mcg/
min IV, or 0.04-0.08 mcg/kg/
arrhythmogenic than alternative
2 mcg/mL solution.
kg/min IV CRI
min IV CRI
drugs and therefore rarely
used in veterinary medicine.
Contraindicated in tachycardia
or AV block caused by cardiac
glycoside intoxication.
Isosorbide dinitrate (Isordil, Adjunctive therapy for CHF: As Adjunctive therapy for CHF: As Adverse effects include tachycardia, Tablets, extended-release
Ismo, Imdur) the dinitrate salt 8-10 mg/ the dinitrate salt 8-10 mg/kg restlessness, or GI effects. Use tablets
kg PO q 12h; as the PO q 12h; as the mononitrate with extreme caution in patients
mononitrate 0.5-2 mg/DOG 0.5-2 mg/CAT PO q 12h with low blood pressure or
PO q 12h hypovolemia. Do not use as a
monotherapy.
Isotretinoin (Accutane) Sebaceous skin disorders: Feline acne: 5-10 mg/CAT PO Do not use in homes with Capsules; give with food.
1 mg/kg PO q 12-24h q 24h a pregnant woman. Use
with extreme caution in
hypertriglyceridemia, severe renal
or hepatic disease. Hairless skin
may sunburn more easily. Adverse
effects include KCS in dogs, GI
distress, behavioral changes
from CNS effects, and pruritus.
Cats have more severe reactions,
including blepharospasm,
periocular crusting, erythema,
diarrhea, and weight loss due to
anorexia.
Itraconazole (Itrafungol, Susceptible systemic mycoses: Susceptible systemic mycoses: Adverse effects include anorexia, Capsules and oral solutions;
Sporanox) 5-10 mg/kg PO q 24h, or 50-100 mg/CAT or 5-10 mg/ GI upset, hepatotoxicity. Oral give with fatty meal.
5 mg/kg PO q 12h kg PO q 24h, or 5 mg/kg PO solutions contain 15% propylene Compounded forms prepared
q 12h glycol and may cause Heinz from the bulk powder are
body formation in cats. In dogs, not bioavailable in dogs and
erythema multiforme or toxic cats and do not achieve
epidermal necrolysis occurs appropriate therapeutic blood
rarely, and ulcerative skin lesions, levels.
vasculitis, and limb edema may
occur at higher dosages. Use with
caution in hepatic impairment and
in animals with reduced cardiac
function.
Ivermectin (Ivomec, Heartworm prevention: Heartworm prevention: Adverse effects are dose related, Tablets, chewable tablets,
Heartgard) 0.006 mg/kg PO q month 0.024 mg/kg PO q month with low dosages found in oral paste, oral solutions,
Sarcoptic mange: 0.2-0.4 mg/ Sarcoptic mange: 0.2-0.4 mg/ heartworm prevention well pour-on, injectable solutions,
kg PO or SQ q 7 days for 4 kg PO or SQ q 7 days for 4 tolerated. Higher dosages can otic preparations (multiple
treatments treatments cause neurologic adverse effects formulations for different
Ear mites: Otic preparation Ear mites: Otic preparation and should be avoided in dogs purposes in different
topically once or twice topically once or twice with MDR1/ABCB1-Δ mutation. species). Ivermectin for small
Multiple drug interactions animals found at low dose
possible. Off-label use of large in heartworm preventatives,
animal products in dogs or sometimes combined with
cats can cause severe adverse other anthelmintics.
reactions, including death.
Kaolin-pectin (Kaopectolin) Diarrhea: 1-2 mL/kg PO q Diarrhea: 1-2 mL/kg PO q Generally well tolerated. Transient Oral suspension OTC
4-6h prn 4-6h prn constipation may occur with high
doses. Impacts absorption of
other medications. Do not use for
severe diarrhea.

Drug Compendium

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