Page 2829 - Cote clinical veterinary advisor dogs and cats 4th

1492 Melarsomine (Immiticide, Diroban) Mesna (Mesnex)

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
VetBooks.ir Melarsomine (Immiticide, Heartworm infection (class Do not use in cats. Pain at injection site and reluctance Injection. Administer deep
IM strictly following the
Diroban)
1): 2.5 mg/kg deep IM in
to move following treatment is
common. Other adverse effects
the lumbar epaxial muscles
manufacturer’s package insert.
twice, 24 hours apart, or as
for class 2-3 include coughing, gagging, Wear appropriate personal
protective equipment (e.g.,
depression, inappetence, fever,
Heartworm disease (class 2, lung congestion, and vomiting. gloves, gowns, face mask) to
3): 2.5 mg/kg deep IM in Do not administer to dogs with protect from exposure.
the lumbar epaxial muscles; caval syndrome. Post-treatment
enforce strict rest for 1 thrombotic events are strongly
month, then repeat 2 more correlated with activity. Strict
doses 24 hours apart (total of cage rest should be imposed
3 injections) for at least 2-4 weeks after
treatment.
Melatonin (Regulin, PrimeX, Alopecia X: 3-12 mg/DOG PO q Nocturnal hyperactivity: Generally very well tolerated. May Tablets OTC, implants
Dermatonin) 8-24h, or using the implants 1.5-6 mg/CAT PO before cause sedation. Implants are
8 mg (dogs <9 kg), 12 mg bedtime occasionally associated with
(dogs 9-18 kg), and 18 mg injection site reactions.
(dogs >18 kg) implanted SQ
1-2× yearly as needed
Adjunct for immune-mediated
blood disorder: 3 mg/DOG for
dogs <20 kg, and 6 mg/DOG
for dogs >20 kg PO q 12h
Meloxicam (Metacam, Antiinflammatory/analgesic Product bears a black box Adverse events are similar to other Tablets, oral suspension,
Mobic, OroCam) NSAID: 0.2 mg/kg PO, IV, warning about use in cats. NSAIDs and include GI upset, injection, transmucosal oral
or SQ initially, followed by ISFM and AAFP support low ulceration, perforation, and renal solution. Oral forms given
0.1 mg/kg PO q 24h dosing for chronic pain. toxicity. Do not combine with with food.
Chronic antiinflammatory/ other NSAIDs or glucocorticoids.
analgesic NSAID: 0.1 mg/ Manufacturers state that there
kg PO initially, followed by is no known safe dosing of this
0.05 mg/kg PO q 24h tapered drug in cats; however, it is often
to lowest effective dose used as an analgesic for chronic
conditions such as osteoarthritis
in cats.
2
2
Melphalan (Alkeran) Antineoplastic: 2 mg/m PO Antineoplastic: 2 mg/m PO q Use with caution in patients with Tablets. Cytotoxic, NIOSH-listed
q 24h for 2 weeks, then other day; or 0.1 mg/kg PO q leukopenia, thrombocytopenia, hazardous drug and should be
2-4 mg/m PO q 48h; or 24h for 2 weeks, then q 48h previous radiotherapy, impaired prepared, administered, and
2
0.1 mg/kg PO q 24h for 10 hepatic or renal function. disposed of in accordance with
days, then 0.05 mg/kg PO q Adverse effects include GI upset, federal and local requirements.
2
24h; or 1.5 mg/m PO q 24h pulmonary infiltrates or fibrosis,
for 7-10 days; or 7 mg/m q and myelosuppression.
2
24h for 5 days q 3 weeks
Memantine (Namenda) Behavioral disorders: Use is not described in cats. Poor evidence for clinical efficacy Tablets
0.3-0.5 mg/kg PO q 12h or safety in veterinary patients,
though no specific adverse
effects described.
Meropenem (Merrem) Multidrug-resistant infections: Multidrug-resistant infections: Generally well tolerated. Alopecia Injection. Stable at 50 mg/mL in
8.5-12 mg/kg SQ q 12h or 10 mg/kg q 12h SQ, IV or hair color change may occur refrigerator for up to 25 days.
24 mg/kg IV q 12h; increase at SQ injection sites. GI upset
to q 8h if neutropenia and and seizures have been reported.
pathogen minimum inhibitory Do not use in animals that have
concentration >1 known allergies to beta-lactam
antimicrobials.
Mesalamine (5-ASA, Asacol, IBD: 10-20 mg/kg PO q 8h Use is not described in cats. Not commonly used in veterinary Controlled-release capsules
Pentasa) medicine.
Mesna (Mesnex) Adjunctive therapy to ifosfamide Adjunctive therapy to ifosfamide Used as an adjunctive therapy Injection. Dilute 20 mg/mL
for antineoplastic therapy: for antineoplastic therapy: with ifosfamide administration before administration at 20%
Give mesna at 20% of the Give mesna at 20% of and saline diuresis to prevent of ifosfamide dose.
ifosfamide dose as an IV the ifosfamide dose as hemorrhagic cystitis.
bolus initially with ifosfamide an IV bolus initially with
infusion; repeat at 2 and 5 ifosfamide infusion; repeat
hours after the ifosfamide at 2 and 5 hours after the
infusion. Treatment is ifosfamide infusion. Because
repeated q 3 weeks. the dose of ifosfamide is
significantly greater for cats,
the dose of mesna will also
be comparatively larger.
Treatment is repeated q 3
weeks.

www.ExpertConsult.com