Page 2833 - Cote clinical veterinary advisor dogs and cats 4th

1496 Mitoxantrone (Novantrone) Neomycin (Biosol, Neomix)

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
VetBooks.ir Mitoxantrone (Novantrone) Antineoplastic: 5-6 mg/m IV Antineoplastic: 5-6.25 mg/m IV Adverse effects are dose dependent Injection. Cytotoxic, NIOSH-listed
2
2
hazardous drug and should be
once q 3 weeks
GI upset, hepatotoxicity, and
once q 3 weeks
myelosuppression. Neutropenia
prepared, administered, and
nadir usually occurs at about 10
federal and local requirements.
days. Seizures have occurred in disposed of in accordance with
cats. Avoid extravasation. Use
with caution in patients with
myelosuppression, concurrent
infection, hyperuricemia or
hyperuricuria, and impaired
hepatic function.
Morphine sulfate Analgesia: 0.5-1 mg/kg IM, Not commonly used in Adverse events commonly include Tablets, extended-release tablets
SQ, or IV; or 0.1-0.2 mg/ cats due to vomiting and vomiting and decreased intestinal (do not split or crush), oral
kg/h IV CRI hyperexcitability peristalsis. Dogs are likely to solutions, injection, extended-
Epidural use: 0.1 mg/kg in Analgesia: 0.05-0.2 mg/kg IM, experience CNS and respiratory release injection. Administer
0.3 mL/kg saline (max of SQ q 2-6h depression; cats are likely to IV doses slowly to minimize
6 mL) experience CNS hyperstimulation. histamine release. Controlled
Palliative analgesia: immediate- Cats may experience substance. CSS-II.
release morphine 1 mg/kg hyperthermia. Morphine should
PO q 4-6h; sustained-release not be used in patients that have
morphine 2-5 mg/kg PO received an MAO inhibitor in the
q 12h previous 14 days. Contraindicated
in GI obstruction. May cause
histamine release; do not use
in envenomation toxicities or
animals with mast cell tumors.
Mycophenolate mofetil Immunosuppression: 6-15 mg/ Do not use in cats (limited Adverse effects usually include Capsules, compounded oral
(Cellcept, MMF) kg IV or PO q 12h metabolism). GI upset and hemorrhagic suspension, injection. Injection
diarrhea. Myelosuppression is diluted with D 5 W for slow IV
also possible. Reduce dosage in infusion over 2 hours (never
severe renal impairment. Avoid bolus). Infusion incompatible
combination with azathioprine due with other drugs.
to similar mechanism of action.

N

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
Naloxone (Narcan) Opioid reversal: 0.01- Opioid reversal: 0.01-0.04 mg/ Generally well tolerated; however, Injection
0.04 mg/kg IV, IM, SQ; kg IV, IM, SQ; duration of hyperalgesia may occur
duration of action is 45-90 action is 45-90 minutes; when opioids are reversed.
minutes; repeat as needed repeat prn Rapid opioid reversal may
for opioids with long Postanesthetic hyperthermia: result in tachycardia, blood
half-lives 0.01 mg/kg IM or SQ pressure changes, ventricular
arrhythmias, pulmonary edema,
and seizures. Does not work
orally due to large first-pass
effect.
Naltrexone (Trexan, ReVia) Opioid antagonism: 0.0025- Behavioral disorders: Generally well tolerated; Tablets, injection
0.003 mg/kg IV 25-50 mg/CAT PO q 24h however, hyperalgesia may
Behavioral disorders: 2-5 mg/ occur when opioids are
kg PO q 24h reversed. Contraindicated in
hepatic insufficiency. Negates
antitussive effect of opioids.
Neomycin (Biosol, Neomix) Hepatic encephalopathy: Hepatic encephalopathy: Ototoxicity (especially cats) and Oral solution; give with food.
10-20 mg/kg PO q 8-12h 10-20 mg/kg PO q 8-12h nephrotoxicity are not high
risk after oral administration;
however, these may occur if
intestinal disease is present
and neomycin is systemically
absorbed. Avoid in azotemic
patients.

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