Page 2835 - Cote clinical veterinary advisor dogs and cats 4th

1498 Oclacitinib (Apoquel) Oxytocin (Pitocin)

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VetBooks.ir Generic Name (Brand Canine Dosages Feline Dosages Adverse Effects/Warnings Administration/
Availability
Name, Synonyms)
Oclacitinib (Apoquel) Atopic dermatitis: 0.4-0.6 mg/ Hypersensitivity dermatitis: Do not use in animals <12 months old Tablets; give with food.
kg PO q 12h for up to 14 0.4-0.6 mg/kg PO q 12h for up or pregnant. Adverse effects include Wash hands after
days and then q 24h to 14 days and then q 24h GI upset, PU/PD, and lethargy. handling. Pregnant women
Benign cutaneous and subcutaneous should avoid contact with
masses have also been reported. this drug.
May increase susceptibility to
infection or neoplasia. Monitor CBC,
biochemical profile, and urinalysis
periodically.
Octreotide (Sandostatin) Insulinoma: 10-40 mcg/DOG SQ Chylothorax: 10-20 mcg/kg SQ Use with extreme caution in biliary Injection (sustained and
q 8-12h; sustained-release q 8-12h tract dysfunction; may inhibit immediate release)
injection: 0.5 mcg/kg IM q gallbladder contraction. Generally
28 days well tolerated. May cause anorexia.
Ofloxacin (Ocuflox) Ocular infection: 1 drop topically Ocular infection: 1 drop topically Can cause irritation. Ophthalmic solution
in affected eye q 12h in affected eye q 12h
Olsalazine (Dipentum) IBD: 5-20 mg/kg PO q 8h Use is not described for cats. Adverse effects include GI upset Capsules; give with food.
and keratoconjunctivitis sicca. Use
with caution in animals with renal
disease.
Omeprazole (GastroGard, Proton pump inhibitor antacid: Proton pump inhibitor antacid: Well tolerated but may cause GI upset, Tablets and capsules OTC,
UlcerGard, Prilosec) 0.7-1.5 mg/kg PO q 12h; 0.5-1.5 mg/kg PO q 12-24h CNS disturbance, hematologic or compounded into oral
doses up to 2 mg/kg q 12h abnormalities, or proteinuria. Dosage suspensions. Give 30
can be used may need to be reduced in patients minutes before a meal.
with severe hepatic or renal disease.
Ondansetron (Zofran) Antiemetic: 0.5-1 mg/kg PO Antiemetic: 0.1-1 mg/kg IV Generally well tolerated but Tablets, disintegrating
or IV (slowly over 2-15 (slowly), SQ, IM, or PO q 6-12h sedation, constipation, tremors, tablets, injection, or
minutes) q 8-12h; avoid use and arrhythmias reported. May compounded into
in dogs with MDR1/ABCB1-Δ prolong QT interval; use cautiously transdermal gel. Dilute in
mutation in animals with heart disease and saline and give over 2-15
with other arrhythmogenic drugs. minutes when giving IV
Dosage reduction may be required injection.
in severe hepatic dysfunction. Avoid
use in dogs with MDR1/ABCB1-Δ
mutation.
o,p’-DDD: see mitotane
Orbifloxacin (Orbax) Susceptible infections: 2.5 mg/ Susceptible infections: 2.5 mg/ Can cause GI upset or retinal lesions Tablets; give with food (no
kg-7.5 mg/kg, PO q 24h kg-7.5 mg/kg, PO q 24h in cats (less likely than enrofloxacin). iron, dairy, or antacids).
May lower seizure threshold. Use
with caution in hepatic dysfunction.
Avoid in rapidly growing animals.
Ormetoprim- Susceptible infections: 55 mg/ Coccidiosis: 60 mg/kg PO q 24h Adverse effects include GI upset, Tablets
sulfadimethoxine (Primor) kg PO once, then 27.5 mg/kg hypersensitivity, KCS, and
PO q 24h crystalluria. Use with caution
in Doberman pinschers due to
idiosyncratic polyarthritis.
Oseltamivir (Tamiflu) Canine influenza: 2 mg/kg PO q Use is not described for cats. Not effective if used >40 hours Capsules and oral
12h for 5 days after onset of signs. Use in dogs suspension
is controversial. Adverse effects
include GI upset and ataxia.
Oxymorphone (Numorphan) Preanesthesia: 0.1-0.2 mg/kg Analgesia: 0.01-0.05 mg/kg IV, Can cause respiratory and CNS Injections (tablets and
IM, SQ; 0.05-0.22 mg/kg IV IM, SQ q 2-4h prn depression, hypotension, sedation, suppository not used in
Analgesia: 0.05-0.2 mg/kg IV, bradycardia, hyperexcitability animals). Injections may
IM, SQ q 2-4h prn (cats), panting (dogs); reverse with be difficult to obtain as
naloxone. many manufacturers have
stopped producing. CSS-II.
Oxytocin (Pitocin) Induction of labor: mini doses: Induction of labor: mini doses: Generally well tolerated but Injection
0.25-0.5 units/DOG q 15-30 0.25-0.5 units/CAT q 15-30 contraindicated with uterine or
minutes minutes, or 2-5 units/CAT IV, IM, vaginal obstruction or abnormal
Induction of lactation: or SQ once fetus presentation. Correct
2-10 units/DOG IM or Induction of lactation: hypoglycemia or hypocalcemia
intranasally 2-10 units/CAT IM, SQ, or before use.
intranasally once

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