Page 2837 - Cote clinical veterinary advisor dogs and cats 4th

1500 Phenobarbital Plerixafor (Mozobil)

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
VetBooks.ir Phenobarbital Antiepileptic: 2.5-3 mg/kg PO Antiepileptic: 1-3 mg/kg PO q Adverse effects include sedation, PU/ Tablets, injection.
12h and adjusted with target
Compounding pharmacists
PD, polyphagia, blood dyscrasias, and
q 12h and adjusted with
may prepare a stable oral
target range of trough serum
range of trough serum levels
hepatopathy. Cats may experience
levels 15-45 mcg/mL.
Loading dose: 12-24 mg/kg 15-45 mcg/mL. Loading facial excoriations and coagulopathies. suspension. Avoid rapid IV
dose: 12-24 mg/kg IV once
Use cautiously in animals with hepatic
administration (>50 mg/
IV once and then 3-4 mg/kg and then 3-4 mg/kg IV q 20 or renal insufficiency and in animals min); parenteral solutions
IV q 20 minutes until target minutes until target blood with respiratory compromise. Multiple are highly alkaline; avoid
blood level is achieved. level is achieved. drug interactions. extravasation. CSS-IV.
Sialadenosis: 2.6-6 mg/kg
PO q 12h, tapered with
response
Phenoxybenzamine HCl Functional urethral outflow Functional urethral outflow Adverse effects include hypotension, Capsules. Commercial product
(Dibenzyline) obstruction: 0.25 mg/kg PO obstruction: 2.5-7.5 mg/CAT weakness/dizziness, GI upset, miosis, very expensive. USP-grade
q 12h PO q 12-24h increased intraocular pressure, powder for compounding is
Pheochromocytoma: tachycardia, sodium retention and less costly.
0.25-0.5 mg/kg PO q 12h nasal congestion. Use with caution in
then increased to effect up patients with hypotension or CHF.
to a maximum of 2.5 mg/kg
PO q 12h
Phenylephrine (Neo- Rhinitis: 1-2 drops IN q Hypotension: 1-2 mcg/kg/min Adverse effects include CNS stimulation, Topical nose drops (OTC),
Synephrine) 8-24 h IV CRI arrhythmias, and hypertension (blood injection. Oral tablets are
Hypotension: 1-3 mcg/kg/min pressure should be monitored when available for human use,
as IV CRI, adjusted to effect administering IV). Contraindicated in but use is not described for
severe hypertension and ventricular animals. Topical use with
tachycardia. Use with caution in pediatric ( 8 th% = 0.125%)
1
patients with hyperthyroidism and or diluted products. IV
heart disease. solutions are typically diluted
to 0.1-0.4 mg/mL in normal
saline.
Phenylpropanolamine (Proin) Urethral sphincter mechanism Urethral sphincter mechanism Generally well tolerated, but adverse Flavored tablets. Oral liquids
incompetence: 1-2 mg/kg incompetence: 1-2 mg/kg effects include GI upset, anxiety, are available in Canada, but
PO q 8h PO q 8-12h urine retention, tachycardia, and must be compounded in the
hypertension. Use with extreme United States.
caution in glaucoma, hyperthyroidism,
DM, cardiovascular disorders, kidney
insufficiency, or hypertension.
Phenytoin (Dilantin) Ventricular arrhythmias: Do not use in cats. Adverse effects include GI upset, ataxia, Tablets, capsules, oral
10 mg/kg slowly IV; sedation, hepatopathy, and gingival suspension, injection. Doses
30-50 mg/kg PO q 8h hyperplasia. Not effective as an administered IV are undiluted
(rarely indicated) anticonvulsant. IV use contraindicated at a rate of not more than
Anticonvulsant: No longer in 2nd- or 3rd-degree heart block, 50 mg/min.
recommended sinoatrial block, or sinus bradycardia.
Multiple drug interactions.
Phytonadione: see vitamin K
Pimobendan (Vetmedin) CHF: 0.25 mg/kg PO q CHF: 0.25 mg/kg PO q 12h, Well tolerated, but adverse effects Tablets. Give on empty
12h, adjusted upward adjusted upward as indicated include GI upset and worsening stomach.
as indicated by clinical by clinical response of arrhythmias. Contraindicated in
response conditions for which increased cardiac
output poses risk.
Piperacillin + tazobactam Susceptible bacterial sepsis: Susceptible bacterial sepsis: Reduce dosage (both dose and Injection. Solutions for IV
(Zosyn) 40-100 mg/kg IV over 30 40-100 mg/kg IV over 30 frequency) in renal impairment. administration are typically
minutes q 6-8h minutes q 6-8h Use with caution in patients with diluted in a volume of 50 mL
hypernatremia (high sodium content). normal saline.
Adverse effects include injection site
reactions and hypersensitivity.
Piroxicam (Feldene) Antiinflammatory/analgesic Antiinflammatory/analgesic Adverse effects include GI ulceration, Capsules; usually must be
NSAID with antiangiogenic/ NSAID with antiangiogenic/ bleeding, and nephrotoxicity compounded to achieve
antineoplastic properties: antineoplastic properties: (especially cats). Use with caution desired doses. Give with
0.3 mg/kg PO q 24h 0.3 mg/kg PO q 24-72h in patients that have a history of GI food.
bleeding, kidney or liver dysfunction.
Do not use with other NSAIDs or
glucocorticoids.
Plerixafor (Mozobil) Use is not described for dogs. FIV: 0.5 mg/kg SQ q 12h Adverse effects include diarrhea, Injection. Expensive.
nausea, fatigue, injection site
reactions, headache, arthralgia,
dizziness, and vomiting.

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