Page 2842 - Cote clinical veterinary advisor dogs and cats 4th

Sildenafil (Viagra, Revatio) Spironolactone (Aldactone) 1505

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
VetBooks.ir Sildenafil (Viagra, Revatio) Pulmonary hypertension: Pulmonary hypertension: 0.25 Most common adverse effect is GI Tablets. Compounding
upset. Do not use concurrently with
pharmacists may prepare
1-3 mg/kg PO q 8-12h
to 1.6 mg/kg PO q 12h
nitrates. Use with extreme caution
stable oral suspensions.
in patients with resting hypotension,
fluid depletion, severe left ventricular
outflow obstruction, or autonomic
dysfunction.
Silymarin (milk thistle, Marin Hepatoprotectant: 20-50 mg/kg Hepatoprotectant: 10-50 mg/ Generally well tolerated. GI upset may Tablets, capsules, powder;
Plus) PO q 24h kg PO q 24h occur. give on empty stomach.
Some forms OTC.
Silver sulfadiazine (SSD, Dermal injury including burns: Dermal injury including burns: Hypersensitivity can occur. If used on Topical cream. Use dressings
Silvadene) apply topically q 12-24h apply topically q 12-24h large wounds, toxicities associated or Elizabethan collars to
with sulfa-based antibiotics (e.g., prevent licking.
KCS, blood dyscrasia) are possible.
Sodium bicarbonate Metabolic acidosis: mEq Metabolic acidosis: mEq Use with caution as can cause Tablets (OTC), injection. Oral
bicarbonate required = 0.5 bicarbonate required = 0.5 metabolic alkalosis, electrolyte solution can be prepared
× BW (kg) × (desired CO 2 × BW (kg) × (desired CO 2 disorders, CHF, paradoxical CNS from baking soda.
mEq/L - TCO 2 mEq/L); give mEq/L - TCO 2 mEq/L); give acidosis. Contraindicated in alkalosis
1 4 calculated dose slowly IV, 1 4 calculated dose slowly or with excessive GI chloride loss.
and repeat dosing if required IV, and repeat dosing if Use with extreme caution in DKA,
4 hours later required 4 hours later hypocalcemia, CHF, nephrotic
Urine alkalinization: 25-50 mg/ syndrome, hypertension, oliguria,
kg PO q 12h volume overload. Multiple drug
Renal tubular acidosis: interactions.
1-10 mEq/kg/day in divided
doses PO, titrated to
effect and with potassium
supplementation
Sodium iodide Sporotrichosis: 40 mg/kg PO Sporotrichosis: 2.5 mg/kg May cause iodism, which manifests Powder, oral tincture,
q 8-12h PO q 24h; increase dose as GI upset, depression/lethargy, injection. Give with food.
in 2.5 mg/kg increments twitching, hypothermia, and
to effect q 5 days. Other cardiovascular failure; more likely
treatments preferred. in cats. Do not use in animals with
renal failure or severe dehydration.
Sodium stibogluconate Cutaneous leishmaniasis: Use is not described in cats. Adverse effects include pain on Not available in the United
(Pentostam) 30-50 mg/kg IV or SQ q 24h injection, thrombophlebitis, States but can be imported
for 3-4 weeks musculoskeletal pain, hemolytic from other countries or
anemia, leukopenia, GI upset, supplied by the Centers
pancreatitis, myocardial injury and for Disease Control and
arrhythmias, renal toxicity, shock, Prevention if public health
and sudden death. Contraindicated in threat recognized.
renal failure and cardiac arrhythmias.
Sodium thiosulfate Cyanide toxicity: 40-50 mg/ Cyanide toxicity: 150-500 mg/ Generally well tolerated, but Injection
kg IV, or 150-500 mg/kg IV kg IV bolus or CRI +/-sodium hypernatremia, hypotension, GI
bolus, or 150-500 mg/kg CRI nitrite IV; contact animal upset, and metabolic acidosis may
+/-sodium nitrite poison control center for occur.
guidance
Sotalol (Betapace) Tachyarrhythmia: 1-3 mg/kg Tachyarrhythmia: 1-3 mg/kg Adverse effects include dyspnea, Tablets; give on empty
PO q 12h titrated upward to PO q 12h titrated upward bronchospasm, fatigue/dizziness, stomach.
effect to effect nausea, vomiting, and worsening
of arrhythmias. Contraindicated in
bradyarrhythmia, asthma, long Q-T
syndromes, cardiogenic shock or
uncontrolled CHF. Use with caution
in patients with DM, hyperthyroidism,
and renal insufficiency.
Spironolactone (Aldactone) Adjunctive therapy of CHF: Hyperaldosteronism: 2 mg/kg Adverse effects include GI upset Tablets
1-2 mg/kg PO q 12-24h; not PO q 12h titrated prn and electrolyte imbalance. Severe
first-line diuretic Adjunctive for cardiomyopathy: facial excoriations may limit
1-3 mg/kg PO q 12-24h use in cats. Contraindicated in
hypoadrenocorticism, hyperkalemia,
or hyponatremia. Do not administer
Drug Compendium
spironolactone in conjunction
with NSAIDs to dogs with renal
insufficiency.

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