Page 2845 - Cote clinical veterinary advisor dogs and cats 4th

1508 Topiramate (Topamax) Tylosin (Tylan)

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
VetBooks.ir Topiramate (Topamax) Adjunctive antiepileptic: 5-10 mg/ Refractory epilepsy: Adverse effects include GI distress, Tablets, capsules, and
kg PO q 8-12h
extended-release sprinkle
12.5-25 mg/CAT PO q 12h
sedation, ataxia, inappetence, and
irritability. In cats, sedation and
capsules
inappetence have been noted. Use
with caution in hepatic insufficiency.
Torsemide (Demadex) Diuretic for CHF: 0.1-0.4 mg/kg Diuretic for CHF: 0.2-0.3 mg/ Can cause dehydration and potentially Tablets. Compounding
PO q 12-24h kg PO q 12-24h severe electrolyte disturbances. pharmacists may prepare
Use cautiously in significant hepatic stable oral suspensions.
dysfunction, hyperuricemia, or DM. Ensure that plenty of fresh
Torsemide is 10× more potent than drinking water is available
furosemide. Ensure adequate hydration. at all times.
Tramadol (Ultram) Analgesia: 4-10 mg/kg PO q 8h; Analgesia: 1-2 mg/kg PO q Well tolerated but adverse effects Tablets. Compounding
begin at lower end of dose 12h, questionable efficacy include sedation, respiratory pharmacists may prepare
range and titrate upward if depression, and hypersalivation from stable oral suspensions.
needed; analgesic effect may the extremely bitter taste. Use with Salty flavors may mask
be delayed by days to weeks caution in presence of respiratory bitter taste for cats.
depression. Use with caution in CSS-IV.
animals with a history of seizures.
Trazodone (Desyrel) Anxiolytic: 5-7 mg/kg PO q 12h Pre-stressor anxiolytic: Do not use with MAO inhibitors (e.g., Tablets. Compounding
starting dose, adjusted prn. If 50 mg/CAT PO 60-90 amitraz or selegiline) to avoid pharmacists may prepare
given with tramadol, daily dose minutes before event (e.g., hypertension from serotonin syndrome. stable oral suspensions.
should be reduced to 3.5 mg/ travel to veterinary clinic). Well tolerated but adverse effects
kg PO q 12h until tramadol is Doses up to 100 mg/CAT can include sedation (most common),
discontinued. can be used if needed. ataxia, priapism, cardiac conduction
disturbances, increased anxiety, and
hyperreactivity.
Triamcinolone (Vetalog) Antiinflammatory glucocorticoid: Antiinflammatory Adverse effects are usually GI upset Tablets, powder, inhalants,
0.4-0.8 mg/kg IM, SQ, PO q glucocorticoid: 0.4-1 mg/kg after oral use and those typical of ointments and creams,
24h, tapered IM, SQ, PO q 24h, tapered glucocorticoid use (e.g., PU/PD, injection. Give oral
Immunosuppressive: 1.5-2.0 mg/ Immunosuppressive: polyphagia, hypothalamic-pituitary products with food.
kg PO, IM, SQ q 24h, tapered 1.5-3.0 mg/kg PO, IM, SQ suppression). Contraindicated during Less potent than
Intralesional injection of q 24h, tapered active infection or GI ulceration. Use dexamethasone but more
long-acting acetonide: 0.6 mg Intralesional injection of long- with caution in DM, hypertension, potent than prednisolone;
at one site, maximum 1.8 mg acting acetonide: 0.6 mg at CHF, renal insufficiency. No available in intermediate-
total dose, q 3-4 weeks at one site, maximum 1.8 mg mineralocorticoid activity, so oral and long-acting
most total dose, q 3-4 weeks forms sometimes better tolerated (acetonide) forms.
at most than oral predniso(lo)ne. Do not use
concurrently with NSAIDs.
Trientine (Syprine) Copper chelation: 10-15 mg/kg Use in cats is not described. Generally well tolerated. Acute kidney Capsules; give 1-2 hours
PO q 12h injury has occurred in dogs. Chronic before meals. Very
dosing has resulted in dystonias, muscle expensive.
spasms, and iron-deficiency anemia.
Trilostane (Vetoryl) Hyperadrenocorticism: Hyperadrenocorticism: Generally well tolerated. Adverse Capsules. Can be
2.2-7.0 mg/kg/d, may divide 3.0-5.0 mg/kg PO q effects include GI upset and mild compounded into stable
q 12h; adjust based on ACTH 12-24h; adjust based on hyponatremia/hyperkalemia. Adrenal solution. Give with food.
stimulation test and clinical ACTH stimulation test and necrosis and death have occurred.
response clinical response
Trimethoprim/
sulfamethoxazole: see
sulfamethoxazole/
trimethoprim
Trimeprazine with Antihistamine with glucocorticoid: Antihistamine with Adverse effects are sedation, GI upset, Tablets; give with food.
prednisolone (Temaril-P) 1 tab/5 kg BW PO q 12h for glucocorticoid: 1 and adverse effects of glucocorticoids
4-7 days, then 1 tab/5 kg BW tab/CAT PO q 12h (5 mg (e.g., PU/PD, polyphagia).
PO q 24h for 4-7 days, then 1 trimeprazine/2 mg Contraindicated in presence of viral
tab/5 kg BW PO q 48h prednisolone) or systemic fungal infections, GI
ulceration, and hyperadrenocorticism.
Use with caution in hypertension,
CHF, renal insufficiency. Do not use
concurrently with NSAIDs.
Tropicamide (Mydriacyl) Mydriasis: 1 drop in the affected Mydriasis: 1 drop in the Adverse effects include sensitivity to Ophthalmic solution
eye(s) q 8-12h affected eye(s) q 8-12h bright light, burning and irritation upon
application, and superficial punctate
keratitis. Hypersalivation may also occur.
Tylosin (Tylan) Antibiotic-responsive diarrhea: Use in cats is not described. Generally well tolerated. May cause mild Powder; give with food.
11-25 mg/kg PO q 24h; 11 GI upset.
mg/kg PO q 12h for 28 days
(cryptosporidiosis)

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