Page 2844 - Cote clinical veterinary advisor dogs and cats 4th

Telmisartan (Semintra, Micardis) Toceranib (Palladia) 1507

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
VetBooks.ir Telmisartan (Semintra, Proteinuria: 0.5-1 mg/kg PO Proteinuria: 1 mg/kg PO q Adverse effects include hypotension, GI Tablets, compounded oral
24h
upset, and anemias. Contraindicated in
solution. Expensive.
q 12-24h; titrate up prn to
Micardis)
maximum 5 mg/kg/d
pregnancy. Do not use in uncorrected
hypovolemia or electrolyte imbalance.
Terbinafine (Lamisil) Susceptible systemic mycoses: Susceptible dermatologic Generally well tolerated, but GI upset, Tablets, granules; give with
30-35 mg/kg PO q 8-12h, mycosis: 20-30 mg/kg facial dermatitis, or swelling can food.
often combined with other PO q 24h for 7 days, skip occur. Use with caution and adjust
antifungal 21 days and repeat pulse dosing in patients with renal and
Malassezia: 30 mg/kg PO q 24h dosing hepatic insufficiency.
Terbutaline (Brethine) Bronchodilator, beta agonist: Bronchodilator, beta agonist Adverse effects include increased heart Tablets, injection (do not
1.25-5 mg/DOG PO q 8-12h; acute use: 0.01 mg/kg SQ rate, tremors, CNS excitement, and administer injections IV)
commonly used scheme or IM once; chronic use: dizziness. Use with caution if at all in
0.625-1.25 mg for small dogs; 0.625-1.25 mg/CAT PO DM, hyperthyroidism, hypertension,
1.25-2.5 mg for medium dogs; q 12h seizure disorders, or cardiac disease.
2.5-5 mg for large dogs; PO Do not administer injections IV.
q 12h
Tocolytic for premature labor:
0.03 mg/kg PO q 8h
Testosterone Hormone-responsive urinary Use in cats is not described. Contraindicated in pregnancy. Use with Injection (tablets available
incontinence in males: 2.2 mg/ caution in patients with renal, cardiac, but dosing not described
kg IM q 30 days or hepatic dysfunction. Not for use in animals). CSS-III.
in female animals. Adverse effects
include perianal adenomas, perineal
hernias, prostatic disorders, and
behavioral changes (aggression).
Theophylline Bronchodilator: 10 mg/kg PO Bronchodilator: 15-25 mg/kg Adverse effects include CNS stimulation Give with food to minimize
q 12h PO q 24h and GI upset. Other adverse effects GI upset. Sustained-
include insomnia, increased gastric release tablets are
acid secretion, diarrhea, PU/PD. Use no longer available.
with extreme caution in severe cardiac Immediate-release
disease, seizure disorders, gastric capsules may be
ulcers, hyperthyroidism, renal or hepatic prepared by compounding
disease (50% dosage reduction), severe pharmacists.
hypoxia, or severe hypertension.
Thiamine (vitamin B 1) Thiamine deficiency: Thiamine deficiency: Generally well tolerated. Pain on injection Tablets OTC, injection
10-100 mg/DOG IM, IV, PO 50-100 mg/CAT IM, IV, PO has been reported. Hypersensitivity to
q 12h q 12h excipients may cause anaphylactoid
reactions.
Ticarcillin-clavulanate Susceptible infection: 20-50 mg/ Susceptible infection: Generally well tolerated but can cause Not commercially available
(Timentin) kg IV q 6-8h 20-50 mg/kg IV q 6-8h anaphylaxis or allergic reactions. at present
Tiletamine zolazepam Sedation for minor procedures: Sedation for minor Respiratory depression, pain on Injection. CSS-III.
(Telazol) 9.9-13.2 mg/kg IM (lower dose procedures: 9.9-13.2 mg/ injection, and tachycardia often
may be adequate for restraint) kg IM occur. Contraindicated in animals
with severe cardiac, pulmonary,
or pancreatic disease. May cause
prolonged recoveries in animals with
renal disease.
Timolol (Timoptic) Glaucoma: 1 drop in the affected Glaucoma: 1 drop in the May cause transient burning, stinging, Ophthalmic solution
eye(s) q 12h affected eye(s) q 12h and irritation upon application. May
cause slight miosis. Timolol maleate
may trigger attacks in cats with
asthma and should not be used
in cats with heart disease due to
bradycardia.
Toceranib (Palladia) Antineoplastic: 2.4-2.75 mg/kg Antineoplastic: 2.75 mg/ Adverse GI effects are likely, and the Tablets; give with food.
PO q 48h is better tolerated kg PO q 48h or on a manufacturer recommends concurrent
with less toxicities than the Monday-Wednesday-Friday treatment with prokinetics and
labeled dose type schedule gastroprotectants. Other adverse
effects include muscle cramping/
pain, neutropenia, hypoalbuminemia,
thromboembolic disease, vasculitis,
pancreatitis, nasal depigmentation,
change in coat or skin color, epistaxis,
seizures, pruritus, and increased
systolic blood pressure. May cause Drug Compendium
thromboemboli and edema. Mast cell
degranulation during treatment may
require discontinuation of therapy. Do
not use in pregnant animals.
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