Page 2849 - Cote clinical veterinary advisor dogs and cats 4th

1510.e2 Drug Interactions

Target Drug
Concurrent Plasma
VetBooks.ir Primary Other Drugs Other Drugs With Target Administration Target Drug Binding
Protein
Administration Concurrent
That Increase
Worsens the
With Target
Drug
That Decrease
(Higher %
Metabolism
Blood Levels
the Effect of
Blood Levels
the Effect of
Drugs With
Associated With
Enzymes/ Target Drug Target Drug Enhances Drug Inhibits Adverse Effects Displaces
Target Drug Elimination or Effects or Effects These Drugs These Drugs These Drugs Lower %)
Deracoxib Hepatic/fecal Warfarin, heparin, Benazepril, Aspirin, firocoxib, 90%
excretion clopidogrel, enalapril, robenacoxib,
digoxin, insulins, captopril, lisinopril, meloxicam, prednisone,
glipizide desmopressin, prednisolone,
furosemide, dexamethasone,
torsemide, atenolol, triamcinolone,
telmisartan, methylprednisolone,
candesartan cyclosporine,
dacarbazine,
methotrexate
Diethylstilbestrol Phase II Fluconazole, Phenobarbital, Prednisone, Amitriptyline, Amitriptyline, 95%
glucuronidation/ itraconazole, phenytoin, rifampin prednisolone, clomipramine, clomipramine,
fecal and urinary ketoconazole, dexamethasone, imipramine, imipramine, warfarin
excretion cimetidine, hydrocortisone, warfarin
erythromycin, methylprednisolone,
clarithromycin triamcinolone
Domperidone Hepatic Fluconazole, Anticholinergic Bromocriptine, Enrofloxacin, 93%
metabolism itraconazole, drugs, opioids cabergoline ciprofloxacin,
through CYP3A4 ketoconazole, marbofloxacin,
cimetidine, orbifloxacin,
erythromycin, procainamide,
clarithromycin quinidine, sotalol,
amitriptyline,
imipramine,
clomipramine
Enrofloxacin Hepatic/renal Flunixin, Antacids, dairy, Doxorubicin, Levothyroxine, Cyclosporine, 34%
excretion probenecid aluminum, methotrexate, mycophenolate, enrofloxacin,
magnesium, sildenafil, nitrofurantoin ciprofloxacin,
calcium, iron, zinc, theophylline, marbofloxacin,
sucralfate warfarin orbifloxacin,
procainamide,
quinidine, sotalol,
amitriptyline,
imipramine,
clomipramine,
corticosteroids
Estriol Phase II Cimetidine, Phenobarbital, Levothyroxine Diethylstilbestrol 78.60%
glucuronidation/ clarithromycin, phenytoin, rifampin
fecal and biliary azithromycin,
excretion ketoconazole,
itraconazole,
fluconazole
Fenbendazole Hepatic/fecal Dibromsalan, Not reported
excretion tribromsalan
Firocoxib Phase II Fluconazole Warfarin, heparin, Benazepril, Aspirin, deracoxib, 98%
dealkylation and clopidogrel, enalapril, firocoxib, robenacoxib,
glucuronidation digoxin, insulins, captopril, lisinopril, meloxicam, prednisone,
with biliary and glipizide desmopressin, prednisolone,
hepatic excretion furosemide, dexamethasone,
torsemide, atenolol, triamcinolone,
telmisartan, methylprednisolone,
candesartan cyclosporine,
dacarbazine,
methotrexate
Fluralaner Fecal excretion Carprofen, warfarin 100%
Grapiprant Primarily fecal/ Aspirin, deracoxib, 95%
biliary excretion firocoxib, robenacoxib,
meloxicam, prednisone,
prednisolone,
dexamethasone,
triamcinolone,
methylprednisolone

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