Page 2852 - Cote clinical veterinary advisor dogs and cats 4th

Target Drug
Concurrent Plasma
VetBooks.ir Primary Other Drugs Other Drugs With Target Administration Target Drug Binding
Protein
Administration Concurrent
That Increase
With Target
That Decrease
Drug
Worsens the
(Higher %
Metabolism
Drugs With
the Effect of
the Effect of
Associated With
Blood Levels
Enzymes/ Target Drug Target Drug Enhances Drug Inhibits Adverse Effects Displaces
Blood Levels
Target Drug Elimination or Effects or Effects These Drugs These Drugs These Drugs Lower %)
Trilostane Phase II Aminoglutethimide, Benazepril, captopril, Not reported
hydroxylation ketoconazole, enalapril, lisinopril,
and mitotane spironolactone,
glucuronidation/ potassium supplements
renal excretion
Tylosin tartrate Biliary/renal Bentonite Digoxin Digoxin 25%-47%
excretion

Drug Compendium

www.ExpertConsult.com