Page 2855 - Cote clinical veterinary advisor dogs and cats 4th

Other Considerations for Drug Use in Dogs With MDR1/ABCB1-Δ
VetBooks.ir Drug Consideration Possible Response
The hypothalamic-pituitary-adrenal axis is suppressed in homozygous
In severe stress situations, physiologic doses of corticosteroids may be
Corticosteroids
required in homozygous dogs
dogs
Doxycycline Transported by the ABCB1 P-glycoprotein transporter Doxycycline has a wide therapeutic index and has been used safely at
various doses in a variety of heterozygous and homozygous dogs
Ketoconazole Inhibits the P-glycoprotein transporter pump and is known to induce a Avoid use of ketoconazole in wild type (normal dogs) concurrently with
phenotype similar to an ABCB1 heterozygous or homozygous mutant drugs known to cause severe adverse effects in dogs with the ABCB1
P-gp mutation
Amiodarone Inhibits the ABCB1 P-glycoprotein transporter pump in humans and may Use with caution concurrently with drugs known to cause severe adverse
induce a phenotype similar to an ABCB1 heterozygous or homozygous effects in dogs with the ABCB1 P-gp mutation
mutant
Carvedilol Inhibits the ABCB1 P-glycoprotein transporter pump in humans and may Use with caution concurrently with drugs known to cause severe adverse
induce a phenotype similar to an ABCB1 heterozygous or homozygous effects in dogs with the ABCB1 P-gp mutation
mutant
Clarithromycin Inhibits the ABCB1 P-glycoprotein transporter pump in humans and may Use with caution concurrently with drugs known to cause severe adverse
induce a phenotype similar to an ABCB1 heterozygous or homozygous effects in dogs with the ABCB1 P-gp mutation
mutant
Itraconazole Inhibits the ABCB1 P-glycoprotein transporter pump in humans; Use with caution concurrently with drugs known to cause severe adverse
however, it is not as likely as ketoconazole to induce a phenotype effects in dogs with the ABCB1 P-gp mutation
similar to an ABCB1 heterozygous or homozygous mutant
Quinidine Inhibits the ABCB1 P-glycoprotein transporter pump in humans and Likely to inhibit the canine ABCB1 P-glycoprotein transporter pump. Use
is likely to induce a phenotype similar to an ABCB1 heterozygous or with caution concurrently with drugs known to cause severe adverse
homozygous mutant effects in dogs with the ABCB1 P-gp mutation
Ritonavir Inhibits the ABCB1 P-glycoprotein transporter pump in humans and may Use with caution concurrently with drugs known to cause severe adverse
induce a phenotype similar to an ABCB1 heterozygous or homozygous effects in dogs with the ABCB1 P-gp mutation
mutant
Verapamil Inhibits the ABCB1 P-glycoprotein transporter pump in humans and Known to inhibit the canine ABCB1 P-glycoprotein transporter pump.
is known to induce a phenotype similar to an ABCB1 heterozygous or Use with caution concurrently with drugs known to cause severe adverse
homozygous mutant effects in dogs with the ABCB1 P-gp mutation

Drug Compendium

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