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Glucocorticoid Comparisons 1510.e7

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Glucocorticoid Comparisons

Relative Equivalent Relative Plasma Half-Life Biologic Half-
Antiinflammatory Pharmacologic Mineralocorticoid Dogs/People Life in People
Potency Dose (mg) Potency (Hours) (Hours)
Short-Acting Glucocorticoids
Hydrocortisone 1 20 2 1/1.5 8-12
Cortisone 0.8 25 2 ?/1.5 8-12
Intermediate-Acting Glucocorticoids Clinical Algorithms
Prednisone 4 5 1 ?/1 12-36
Prednisolone 4 5 1 1-3/2-3 12-36
Methylprednisolone 5 4 0 1.5/3 12-36
Triamcinolone 5 4 0 ?/4 or more 24-48
Long-Acting Glucocorticoids
Dexamethasone 30 0.75 0 2/5 or more 35-54
Betamethasone 30 0.6 0 ?/5 or more >48
From Cohn LA: Glucocorticoid therapy. In Ettinger SJ, Feldman EC, editors: Textbook of veterinary internal medicine, ed 7, St. Louis, 2010, Saunders.

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