Page 2851 - Cote clinical veterinary advisor dogs and cats 4th

1510.e4 Drug Interactions

Target Drug
Concurrent Plasma
VetBooks.ir Primary Other Drugs Other Drugs With Target Administration Target Drug Binding
Administration Concurrent
Protein
Drug
That Increase
That Decrease
With Target
Worsens the
(Higher %
Metabolism
Drugs With
Blood Levels
Blood Levels
the Effect of
the Effect of
Associated With
Enzymes/ Target Drug Target Drug Enhances Drug Inhibits Adverse Effects Displaces
Target Drug Elimination or Effects or Effects These Drugs These Drugs These Drugs Lower %)
Phenylpropanolamine Renal excretion Aspirin Isoflurane, desflurane, Not reported
sevoflurane, amitraz,
selegiline, aspirin,
carprofen, deracoxib,
firocoxib, robenacoxib,
meloxicam,
reserpine, ephedrine,
clomipramine,
amitriptyline,
imipramine
Pimobendan Extensive hepatic Verapamil, 90%-95%
metabolism/fecal propranolol,
excretion diltiazem
Potassium bromide Renal excretion Chloride, xylazine, Opioids, CNS 0%
furosemide, depressants
hydrochlorothiazide,
torsemide
Pradofloxacin Hepatic/renal Flunixin, Antacids, dairy, Doxorubicin, Levothyroxine, Cyclosporine, 37% (dogs),
excretion probenecid aluminum, methotrexate, mycophenolate, enrofloxacin, 31% (cats)
magnesium, sildenafil, nitrofurantoin ciprofloxacin,
calcium, iron, zinc, theophylline, marbofloxacin,
sucralfate warfarin orbifloxacin,
procainamide,
quinidine, sotalol,
amitriptyline,
imipramine,
clomipramine,
corticosteroids
Robenacoxib Phase II Fluconazole Warfarin, heparin, Benazepril, Aspirin, deracoxib, >99%
dealkylation and clopidogrel, enalapril, firocoxib, robenacoxib,
glucuronidation digoxin, insulins, captopril, lisinopril, meloxicam, prednisone,
with biliary and glipizide desmopressin, prednisolone,
hepatic excretion furosemide, dexamethasone,
torsemide, atenolol, triamcinolone,
telmisartan, methylprednisolone,
candesartan cyclosporine,
dacarbazine,
methotrexate
Selamectin Hepatic Amiodarone, Sarmazenil, Benzodiazepines, Spinosad Not reported
metabolism, ketoconazole, flumazenil cetirizine
P-gp transporter itraconazole,
substrate, biliary/ fluconazole,
fecal excretion chloramphenicol,
cimetidine,
fluvoxamine,
clarithromycin,
erythromycin,
cyclosporine,
diltiazem,
quinidine,
verapamil
Spinosad Phase II Cyclosporine, Ivermectin, Ivermectin, selamectin, 99%
glutathione verapamil, moxidectin, moxidectin, milbemycin
conjugation/ ketoconazole, milbemycin,
renal and fecal loperamide selamectin
excretion
Toceranib Hepatic Calcitriol Aspirin, carprofen, 92%
metabolism/fecal deracoxib, firocoxib,
excretion meloxicam,
robenacoxib,
antineoplastic drugs

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