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Drug Interactions 1510.e3

Target Drug
Concurrent Plasma
VetBooks.ir Primary Other Drugs Other Drugs With Target Administration Target Drug Binding
Administration Concurrent
Protein
That Decrease
Worsens the
Drug
With Target
That Increase
(Higher %
Metabolism
Associated With
Blood Levels
Drugs With
Blood Levels
Enzymes/ Target Drug Target Drug Enhances Drug Inhibits Adverse Effects Displaces
the Effect of
the Effect of
Target Drug Elimination or Effects or Effects These Drugs These Drugs These Drugs Lower %)
Ivermectin Hepatic Amiodarone, Sarmazenil, Benzodiazepines, Spinosad 93% (humans)
metabolism ketoconazole, flumazenil cetirizine
through CYP3A4 itraconazole,
and, to a lesser fluconazole,
extent, by chloramphenicol,
CYP2D6 and cimetidine,
CYP2E1, P-gp fluvoxamine,
transporter clarithromycin,
substrate, biliary/ erythromycin,
fecal excretion cyclosporine,
diltiazem,
quinidine,
verapamil
Marbofloxacin Hepatic/renal Flunixin, Antacids, dairy, Doxorubicin, Levothyroxine, Cyclosporine, 34%
excretion probenecid aluminum, methotrexate, mycophenolate, enrofloxacin,
magnesium, sildenafil, nitrofurantoin ciprofloxacin,
calcium, iron, zinc, theophylline, marbofloxacin,
sucralfate warfarin orbifloxacin,
procainamide,
quinidine, sotalol,
amitriptyline,
imipramine,
clomipramine,
corticosteroids
Maropitant Hepatic Verapamil Fentanyl, 99.50%
metabolism butorphanol,
through colchicine,
CYP2D15 and cisapride
CYP3A12
Milbemycin Hepatic Amiodarone, Sarmazenil, Benzodiazepines, Spinosad 98%
metabolism, ketoconazole, flumazenil cetirizine
P-gp transporter itraconazole,
substrate, biliary/ fluconazole,
fecal excretion chloramphenicol,
cimetidine,
fluvoxamine,
clarithromycin,
erythromycin,
cyclosporine,
diltiazem,
quinidine,
verapamil
Moxidectin Hepatic Amiodarone, Sarmazenil, Benzodiazepines, Spinosad Not reported
metabolism, ketoconazole, flumazenil cetirizine
P-gp transporter itraconazole,
substrate, biliary/ fluconazole,
fecal excretion chloramphenicol,
cimetidine,
fluvoxamine,
clarithromycin,
erythromycin,
cyclosporine,
diltiazem,
quinidine,
verapamil
Oclacitinib Extensive hepatic Cyclosporine 66%-69%
metabolism/renal
excretion
Drug Compendium

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