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1510.e6 Considerations for Drug Use in Dogs With MDR1/ABCB1-Δ Genetic Mutations

Considerations for Drug Use in Dogs With MDR1/ABCB1-Δ Genetic Mutations
VetBooks.ir Adverse Events and Dose Adjustments for Dogs With MDR1/ABCB1-Δ Genetic Mutations

RECOMMENDED % DOSE REDUCTION
(IF KNOWN)
Drug Adverse Event Heterozygous Homozygous
Acepromazine Profound and prolonged sedation 25% 30%-50%
Actinomycin D Bone marrow suppression, gastrointestinal (GI) toxicity 25% 50%
Apomorphine Severe central nervous depression
Butorphanol Profound and prolonged sedation 25% 30%-50%
Docetaxel Bone marrow suppression, GI toxicity 25% 50%
Doramectin Safe at labeled heartworm prevention dose; higher doses (10-20×) cause neurologic toxicity Avoid higher doses Avoid higher doses
Doxorubicin Bone marrow suppression, GI toxicity 25% 50%
Emodepside Neurologic toxicity Avoid Avoid
Eprinomectin Safe at labeled heartworm prevention dose; higher doses (10-20×) cause neurologic toxicity Avoid higher doses Avoid higher doses
Erythromycin Neurologic toxicity Avoid Avoid
Ivermectin Safe at labeled heartworm prevention dose; higher doses (300-600 mcg/kg) cause neurologic Avoid higher doses Avoid higher doses
toxicity
Loperamide Severe central nervous depression Avoid Avoid
Milbemycin Safe at labeled heartworm prevention dose; higher doses (10-20×) cause neurologic toxicity Avoid higher doses Avoid higher doses
Moxidectin Safe at labeled heartworm prevention dose; higher doses (10-20×) cause neurologic toxicity Avoid higher doses Avoid higher doses
Ondansetron Severe central nervous depression Avoid Avoid
Paclitaxel Bone marrow suppression, GI toxicity 25% 50%
Selamectin Safe at labeled heartworm prevention dose; higher doses (10-20×) cause neurologic toxicity Avoid higher doses Avoid higher doses
Vinblastine Bone marrow suppression, GI toxicity 25% 50%
Vincristine Bone marrow suppression, GI toxicity 25% 50%
Vinorelbine Bone marrow suppression, GI toxicity 25% 50%

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