Page 2839 - Cote clinical veterinary advisor dogs and cats 4th

1502 Prednisolone sodium succinate Propranolol (Inderal)

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
VetBooks.ir Prednisolone sodium Glucocorticoid. Glucocorticoid. Contraindicated in the presence of Injection. IV doses are typically
succinate
further diluted in normal
Shock of multiple causes:
viral or systemic fungal infections, GI
Shock of multiple causes:
ulceration, and hyperadrenocorticism.
5-11 mg/kg IV slow bolus;
saline before administration.
5-11 mg/kg IV slow bolus;
repeat up to q 6h
repeat up to q 6h
Do not use concurrently with NSAIDs.
Use with caution in hypertension,
CHF, renal insufficiency. Can cause GI
ulceration.
Prednisolone, prednisone Glucocorticoid effects (and Glucocorticoid effects (and Dose-dependent adverse effects include Tablets, oral solution. Give with
(Cortef) uses) vary with dose. uses) vary with dose. PU/PD, polyphagia, and suppression food, usually in morning.
Physiologic replacement: Physiologic replacement: of the hypothalamic pituitary axis. Topical, ophthalmic, and otic
0.2-0.3 mg/kg PO q 24h 0.2-0.3 mg/kg PO q 24h Contraindicated in the presence of preparations of prednisolone
Antiinflammatory: 0.5-1 mg/kg Antiinflammatory: 0.5-1 mg/kg active infections, GI ulceration, and available. For cats,
PO q 24h PO q 24h hyperadrenocorticism. Do not use prednisolone preferred over
Immunosuppression: 2-4 mg/ Immunosuppression: 2-4 mg/ concurrently with NSAIDs or other prednisone by any route.
kg PO q 24h kg PO q 24h glucocorticoids. Use with caution in
Adjunct therapy for neoplasia: Adjunct therapy for neoplasia: hypertension, CHF, DM, and renal
2
2
40 mg/m PO q 24h for 7 40 mg/m PO q 24h for 7 insufficiency.
2
2
days; then 20 mg/m PO days; then 20 mg/m PO
q 48h q 48h
Pregabalin (Lyrica) Neuropathic pain: 2-4 mg/kg Use is not described for cats. The most common adverse effects are Capsules, oral solution. CSS-V.
PO q 8-12h sedation and ataxia. Use with caution
in patients with renal insufficiency or
heart failure.
2
Procarbazine (Matulane) Antineoplastic: 25-50 mg/m 2 Antineoplastic: 50 mg/m PO GI upset, hepatotoxicity, and Capsules. Cytotoxic,
PO q 24h q 24-48h myelosuppression are the most NIOSH-listed hazardous drug
common adverse effects. May also and should be prepared,
cause CNS depression. Platelet nadir administered, and disposed
usually occurs at 3-4 weeks. of in accordance with federal
and local requirements.
Propantheline (Pro-Banthine) Antimuscarinic for sinus Detrusor hypercontractility: Adverse effects are dose-related and Tablets
bradycardia: 0.25-5 mg/kg 0.25-0.5 mg/kg or are similar to those of atropine
PO q 8-12h 7.5 mg/CAT PO q 8-12h (e.g., dry mouth and eyes,
Detrusor hypercontractility: tachycardia, constipation). GI upset
0.25-0.5 mg/kg PO q 8-12h and hypersalivation are reported in
cats. High dose can cause ileus.
Use with caution in hepatic disease,
renal disease, hyperthyroidism,
hypertension, CHF, tachyarrhythmias,
prostatic hypertrophy, esophageal
reflux, or hot environmental conditions
(heat prostration).
Propofol (PropoFlo, Diprivan, Ultrashort anesthetic: 3-6 mg/ Ultrashort anesthetic: 3-6 mg/ Adverse effects include respiratory Injection. Administer IV slowly
PropoFlo-28) kg IV; 0.2-0.5 mg/kg/min IV kg IV; 0.2-0.5 mg/kg/min IV depression, hypothermia, and over 60-90 seconds to avoid
CRI, titrated to effect CRI, titrated to effect seizurelike activity. Cats, greyhounds, apnea, titrating to effect.
and very thin animals may have more
profound effects. Prolonged CRIs may
cause Heinz body formation in cats.
Some formulations contain excipients
that may cause histamine release in
dogs. Some formulations contain high
levels of benzyl alcohol, which may be
problematic in cats. Use with caution
in animals with cardiovascular or
respiratory depression.
Propranolol (Inderal) Susceptible tachyarrhythmias: Susceptible tachyarrhythmias: Adverse effects include GI upset, Tablets, capsules, oral
IV: 0.02 mg/kg IV slowly IV: 0.02 mg/kg IV slowly over syncope, bradycardia, depression, solution, injection. Dilute IV
over 2-3 minutes; titrate 2-3 minutes; titrate dose up impaired AV conduction, CHF, doses in D 5 W and administer
dose up to effect (to a to effect (to a maximum of hypotension, hypoglycemia, and slowly at not more than
maximum of 0.1 mg/kg), 0.1 mg/kg); 2.5 mg/CAT PO q bronchoconstriction. Contraindicated 1 mg/min.
repeated in 8 hours prn; 8-12h, maximum 10 mg/CAT/ in CHF, bradyarrhythmias, and
or 0.1-0.2 mg/kg PO q dose bronchospasm. Reduce dosing in
8h, titrated to effect up to hepatic insufficiency. Use cautiously
a maximum of 1.5 mg/kg in diabetics.
PO q 8h

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