Page 2840 - Cote clinical veterinary advisor dogs and cats 4th

Protamine sulfate Rabeprazole (AcipHex) 1503

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
VetBooks.ir Protamine sulfate Heparin overdose: 1 mg Heparin overdose: 1 mg Generally well tolerated. Acute Injection. Can dilute in normal
protamine/100 U of heparin
protamine/100 U of heparin
saline or D 5 W for slow IV
hypotension, bradycardia, pulmonary
overdose. Ideally given
overdose. Ideally given
injection at a rate of not
hypertension, and dyspnea may occur
immediately by slow IV
infusion. Can repeat prn,
infusion. Can repeat prn, immediately by slow IV if injected IV rapidly. more than 50 mg/10 min.
reducing protamine dose reducing protamine dose
50% for q 30-60 minutes 50% for q 30-60 minutes
post heparin overdose. post heparin overdose.
Psyllium mucilloid Bulk laxative: 0.5-5 g, or 1-3 Bulk laxative: 2-4 teaspoons Adverse effects may include flatulence. Powder OTC. Give with food
(Metamucil) teaspoons, PO q 12-24h in PO q 12-24h, in moistened Bowel obstruction may occur if animal and ensure hydration.
moistened food food is not well hydrated. Contraindicated
in intestinal obstruction.
Pyrantel pamoate (Strongid Roundworms/hookworms: Susceptible intestinal parasites: Generally well tolerated. Do not Tablets, oral suspension.
T, Nemex) 5-10 mg/kg PO with food; 10-20 mg/kg PO; repeat as administer to severely debilitated Give with food. OTC forms
repeat in 7-10 days needed animals. Adverse effects are mostly available.
due to GI upset.
Pyridostigmine bromide Myasthenia gravis: 0.2-2 mg/ Myasthenia gravis: 0.25- Adverse effects are dose-related Tablets, extended-release
(Mestinon, Regonol) kg PO q 8-12h with food; 2.0 mg/kg PO q 24h with and include increased GI motility, tablets, oral syrup, injection.
0.01-0.03 mg/kg/h IV CRI food salivation, urination, abdominal pain, Give oral forms with
for fulminant disease diarrhea, bradycardia, and increased food. IV doses should be
lacrimation. Use with caution in administered slowly as a
patients with bronchospastic disease, CRI.
epilepsy, hyperthyroidism, bradycardia
or other arrhythmias, vagotonia, or
GI ulcer diseases. Reduce dosage in
renal impairment.
Pyrimethamine (Daraprim) Susceptible protozoal Use with caution in cats due to Adverse effects include anorexia, Tablets. Pregnant women
infection: 0.5-1 mg/kg PO adverse effect profile. malaise, vomiting, depression, and should avoid handling.
q 24h for 48 hours, then Susceptible protozoal infection: bone marrow depression, which
0.25-0.5 mg/kg PO q 24h 0.5-1 mg/kg PO q 24h for may be more severe in cats. Oral
for 14 days 48 hours, then 0.25 mg/kg administration of folinic acid at 1 mg/
PO q 24h for 14 days kg PO or folic acid 5 mg/day may
alleviate the adverse hematologic and
neurologic effects. Use cautiously
in animals with pre-existing folate
deficiencies.

Q-R

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
Quinidine (Quinaglute, Ventricular arrhythmias: Do not use in cats. Dose-related adverse effects Tablets, injection (do not
Quinidex) 6-16 mg/kg PO or IM q 6-8h include weakness, GI upset, give IV)
hypotension, and arrhythmia.
Contraindicated in myasthenia
gravis, complete AV block with
pacemaker, QRS widening
disorders, digitalis intoxication,
aberrant ectopic impulses, or
abnormal rhythms secondary to
escape mechanisms. Do not use
with digoxin.
Rabeprazole (AcipHex) Acid suppression: 0.7-1 mg/kg Use is not described for cats. Well tolerated but may cause Tablets
PO q 24h GI upset, CNS disturbance,
hematologic abnormalities, or
proteinuria. Dosage may need
Drug Compendium
to be reduced in patients with
severe hepatic or renal disease.

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