Page 2841 - Cote clinical veterinary advisor dogs and cats 4th

1504 Ramipril (Altace, Vasotop) Sertraline (Zoloft)

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
VetBooks.ir Ramipril (Altace, Vasotop) Heart failure: 0.125-0.25 mg/ Arterial hypertension: 0.5 mg/kg Well tolerated but GI upset can Capsules
kg PO q 12h
occur. Weakness, hypotension, or
PO q 24h
hyperkalemia are also possible.
Ranitidine HCl (Zantac) H 2 antagonist antacid and H 2 antagonist antacid and Generally well tolerated but rapid Tablets (OTC), injection
prokinetic: 1-4 mg/kg PO, prokinetic: 2.5 mg/kg slow IV doses may cause arrhythmias, (give slowly IV)
SQ, IM, or slow IV q 8-12h IV q 12h, or 3.5 mg/kg PO vomiting, and hypotension in cats.
q 12h May cause elevated liver enzymes
with chronic use. Use lower doses
in renal insufficiency. Antacid
efficacy limited.
Rifampin (Rifadin) Adjunctive therapy for Susceptible infection: Adverse effects include GI upset Capsules, injection.
susceptible infections: 10-15 mg/kg PO or IV q 24h and hepatopathies. Use with Compounding
5-15 mg/kg PO or IV q caution in hepatic insufficiency; pharmacists may
12-24h rifampin hepatotoxicity can be prepare stable oral
fatal. Will stain tears, urine, suspensions. Give with
saliva, and feces a red-orange food. IV doses should
color. Usually used in combination be diluted with normal
with other antimicrobial drugs. saline or D 5W and
infused slowly.
Rivaroxaban (Xarelto) Oral anticoagulant: 0.5-1 mg/ Oral anticoagulant: 2.5 mg/CAT Clinical experience in pets Tablets
kg PO q 12-24h (anecdotal q 24h (anecdotal dose) is limited. Hemorrhage is
dose) predominant adverse effect and is
more likely when combined with
platelet inhibition.
Robenacoxib (Onsior) Antiinflammatory/analgesic Antiinflammatory/analgesic Adverse events are usually GI in Tablets (give with food),
NSAID: 1-2 mg/kg PO q 24h NSAID: 1-2.4 mg/kg PO q nature but may also include injection
Perioperative analgesia: 2 mg/ 24h nephrotoxicity and hepatotoxicity.
kg SQ once or PO q 24h for Perioperative analgesia: 2 mg/ Use with caution in animals with
3 days kg SQ q 24h × 3 doses or dehydration, hypotension, or with
1-2.4 mg/kg PO q 24h up to impaired cardiac, renal, or hepatic
6 days function. Do not use concurrently
with glucocorticoids or other
NSAIDs. Cats must be monitored
closely for renal toxicity.
Ronidazole Giardiasis (not first-line Tritrichomonas foetus: 30 mg/kg Neurotoxicity has been reported Available only through
treatment): 30-50 mg PO q PO q 24h for 14 days in cats and manifests as compounding. Give with
12h for 7 days tremors, lethargy, anorexia, food. Wear gloves when
ataxia, nystagmus, seizures, administering, and wash
hyperthermia, or behavioral hands afterward.
change. GI upset may also occur.
Rutin (Bioflavonoids) Lymphedema: 50 mg/kg PO Chylothorax: 50 mg/kg or Generally well tolerated Tablets, capsules OTC
q 8h 250 mg/CAT PO q 8h initially,
reducing to q 12h if effective

S

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
S-adenosyl methionine Hepatoprotectant: 20 mg/kg Hepatoprotectant: 20 mg/kg Generally well tolerated. GI upset may Capsules; give on empty
(SAMe, Denosyl) PO q 24h PO q 24h occur. stomach
Selegiline (deprenyl, Anipryl, Cognitive dysfunction: 0.5 mg/ Do not use in cats. Do not use with other MAO inhibitors, Tablets
Eldepryl) kg PO q 24h opioids, SSRIs, or tricyclic
Narcolepsy: 2 mg/kg PO q 24h antidepressants. Adverse effects
include GI upset, CNS effects, and
aggression. Efficacy is questionable.
Sertraline (Zoloft) Behavior modification: Behavior modification: 0.25- Do not use with other MAO inhibitors. Tablets, oral solution
0.5-4 mg/kg PO q 12-24h 1.5 mg/kg PO q 12-24h Adverse effects include GI upset,
CNS effects, and heightened
reactivity. Avoid abrupt withdrawal.

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