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Methadone (Dolophine) Methylphenidate (Ritalin) 1493

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
VetBooks.ir Methadone (Dolophine) Analgesia: Loading dose of Analgesia: Loading dose of Adverse effects are typical for Injection. Dilute in saline for CRI
opioids and include panting,
0.1-0.2 mg/kg IV, followed by
0.1-0.2 mg/kg IV, followed
infusions. CSS-II.
by 0.12 mg/kg/h IV CRI
0.12 mg/kg/h IV CRI
whining, sedation, defecation,
Perioperative and postoperative
analgesia: 0.05-0.5 mg/kg IV,
CNS excitation, histamine
analgesia: 0.1-1 mg/kg IV, Perioperative and postoperative constipation, bradycardia,
SQ, or IM q 4-8h SQ, or IM q 4-6h response, and respiratory
depression. Use with extreme
caution in hypothyroidism,
severe renal insufficiency,
hypoadrenocorticism, in geriatric
or severely debilitated patients,
head injuries, increased
intracerebral pressure, acute
abdominal conditions, respiratory
disease or acute respiratory
dysfunction.
Methazolamide (Neptazane) Glaucoma: 2-5 mg/kg PO Glaucoma: 1-4 mg/kg PO May cause mild metabolic acidosis Tablets. Very expensive. Use
2-3×/d 2-3×/d (bicarbonaturia); GI, CNS adverse may be obsolete due to
effects possible. cost and compared to more
efficacious topical therapies
with fewer side effects.
Methimazole (Tapazole, Functional thyroid neoplasia: Hyperthyroidism: 2.5 mg/CAT PO Adverse effects include GI Tablets. Compounding
Felimazole) 2.5-5 mg/DOG PO q 12h or by transdermal gel q 12h upset, blood dyscrasias, pharmacists may provide oral
(other treatments indicated) initial dose, adjusted based on facial excoriations (requires suspensions and transdermal
response to therapy. Response discontinuation of therapy), gels. Give oral preparations
to transdermal may take and rarely hepatotoxicity and with food. Use gloves when
several weeks. myasthenia gravis. Avoid use in applying topically to inner
autoimmune disease, primary pinnae.
liver disease, hematologic
disorders or coagulopathies, or
pregnant/lactating queens. May
unmask underlying renal failure.
Methionine, DL: see
DL-methionine
Methocarbamol (Robaxin) Muscle relaxation: 20-45 mg/ Muscle relaxation: 20-45 mg/kg Adverse effects include sedation, Tablets, injection. Avoid IM
kg PO q 8-12h; Muscle PO q 8-12h salivation, emesis, lethargy, or SQ injection due to pain,
tremors of toxicoses: weakness, and ataxia. and administer slowly by IV
44-220 mg/kg slow IV; use infusion, being careful to avoid
high end of dose range if extravasation.
strychnine, metaldehyde,
tetanus; maximum 330 mg/
kg/day
2
Methotrexate Antineoplastic: 0.06 mg/kg PO Antineoplastic: 2.5 mg/m PO q Adverse effects include leukopenia, Tablets, injection. Cytotoxic,
q 24-48h; or 2.5 mg/m PO 2-3 days GI bleeding, hepatotoxicity. NIOSH-listed hazardous drug
2
q 24-48h Contraindicated in bone marrow and should be prepared,
depression, severe hepatic or administered, and disposed of
renal insufficiency. in accordance with federal and
local requirements.
Methylene blue (new Methemoglobinemia: 1 mg/ Use in cats is not described. Oxidant compound that can result Available through compounding
methylene blue) kg IV for short-term use, or in magnified oxidative damage
1.5 mg/kg PO q 24-48h for and hemolysis. Use with caution,
chronic use and consider consultation with
veterinary toxicologist or internist.
Methylphenidate (Ritalin) Narcolepsy: 0.1-0.25 mg/kg PO Use in cats is not described. Adverse effects include CNS Tablets, oral solution, oral
q 8-24h stimulation, hyperthermia, suspension. A drug of
tremors, tachycardia, tachypnea, high abuse by humans;
and anorexia. Use with caution prescriptions limited to 30
in seizure disorders, cardiac days. CSS-II.
disease, hypertension, or in
aggressive animals.

Drug Compendium

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