Page 2809 - Cote clinical veterinary advisor dogs and cats 4th

1472 Decoquinate (Deccox) Dexrazoxane (Zinecard, Cardioxane)

Generic Name (Brand Administration/
Name, Synonyms) Canine Dosages Feline Dosages Adverse Effects/Warnings Availability
VetBooks.ir Decoquinate (Deccox) Hepatozoonosis: 10-20 mg/kg PO Dosing is not described for Generally well tolerated. Must be given Powdered feed additive OTC
for >2 years to treat hepatozoonosis.
cats.
q 12h mixed in food
Deferoxamine (Desferal)
Iron chelator: 15 mg/kg/h IV;
reactions, auditory neurotoxicity,
or 40 mg/kg IM q 4-8h for
or 40 mg/kg IM q 4-8h for Iron chelator: 15 mg/kg/h IV; Adverse effects include hypersensitivity Injection; difficult to obtain
48-72 hours until serum iron is 48-72 hours until serum pain or swelling at injection sites,
<300 mcg/dL. Most effective iron is <300 mcg/dL. Most and GI distress. Contraindicated in
within 24 hours of intoxication. effective within 24 hours severe chronic kidney disease and
of intoxication. anuria unless used with dialysis. Will
turn urine a pink color during iron
chelation.
Denamarin: see silymarin
Deracoxib (Deramaxx) Analgesic/antiinflammatory Do not use in cats. Adverse effects are primarily GI Tablets
NSAID: 1-2 mg/kg PO q 24h and renal, though hepatic and
(long-term use); 3-4 mg/kg PO dermatologic events have been
q 24h (maximum 7 days) reported. Do not use with other
NSAIDs or corticosteroids.
Desmopressin acetate Diabetes insipidus: 1 drop Diabetes insipidus: 1 drop of Well tolerated. Occasionally, Tablets and solution for nasal
(DDAVP) of 0.01% solution in the the 0.01% solution in the hypersensitivity reactions have been inhalation. Expensive.
conjunctival sac q 12-24h. conjunctival sac q 12-24h; reported.
Up to 4 drops per dose may 0.25-0.5 mg/CAT PO q
be required in some patients; 8-12h (tablets)
1-2 mcg/kg SQ q 12-24h;
0.1 mg/DOG PO q 8h (tablets)
Desoxycorticosterone Hypoadrenocorticism: 2.2 mg/ Hypoadrenocorticism: Supplemental glucocorticoid therapy Injectable suspension
pivalate (DOCP, kg IM or SQ initially and then 10-12.5 mg/CAT IM per usually required. The injection should
Percorten-V, Zycortal) as needed for disease control month or as needed to be shaken vigorously for 3-4 minutes
(typically once a month) control signs before use to ensure uniformity of
dose. Well tolerated, though lethargy,
GI upset, and other events can occur.
Dexamethasone sodium Glucocorticoid; effects (and uses) Glucocorticoid; effects (and Glucocorticoid 7-10× more potent than Tablets, oral solution,
phosphate (Azium, vary with dose uses) vary with dose prednisone. Adverse effects are those ophthalmic, and injection
Dexate, Decadron) Anaphylaxis: 0.5 mg/kg IV once Anaphylaxis: 0.5 mg/kg IV typical of glucocorticoids (e.g., PU/
Antiinflammatory: 0.1-0.2 mg/kg once PD, polyphagia, GI ulceration, HPA
PO, SQ, or IV q 24h Antiinflammatory: axis suppression, hyperglycemia).
Immunosuppressive: 0.2-0.5 mg/ 0.1-0.2 mg/kg PO, SQ, or Often used for short duration,
kg PO, SQ, or IV q 24h IV q 24h substituting an intermediate-acting
Hypoadrenocortical crisis: Immunosuppressive: glucocorticoid (e.g., prednisone or
0.1-0.5 mg/kg IV; maintenance: 0.2-0.5 mg/kg PO, SQ, or prednisolone) if chronic therapy
<0.1 mg/kg PO prn up to q IV q 24h required. Do not combine with
24h LDDST: 0.1 mg/kg IV once NSAIDs.
LDDST: 0.01 mg/kg IV once
HDDST: 0.1 mg/kg IV once
Dexmedetomidine Sedation/analgesia: 5-10 mcg/ Sedation: 10-20 mcg/kg IM Adverse effects include bradycardia Injection, oromucosal gel
(Dexdomitor, Sileo) kg IM or IV Emesis induction: 7 mcg/ (does not usually require
Preanesthetic: 125-375 mcg/ kg IM or 3.5 mcg/kg IV, treatment), AV block, decreased
m IM and reverse after emesis respiration, hypothermia, urination,
2
Treatment of noise aversion using (which occurs before vomiting, hyperglycemia, and
the oromucosal gel (Sileo): sedation) pain on IM injection. Prolonged
2
125 mcg/m BSA administered sedation, paradoxical excitation,
onto the oral mucosa between hypersensitivity, apnea, and death
the dog’s cheek and gum. from circulatory failure may occur,
The first dose should be although rarely. Often combined with
administered approximately butorphanol or hydromorphone for
30-60 minutes before onset of profound sedation. Adverse effects of
fear stimulus. oromucosal gel are typically limited to
mild sedation.
Dexrazoxane (Zinecard, Prevention of doxorubicin Dosing is not described for May reduce efficacy of doxorubicin and Injection. Wear gloves when
Cardioxane) cardiotoxicity: 10× the cats. increase myelosuppression. handling. Generics available
administered milligram dose of but very expensive.
doxorubicin IV 5-10 minutes
before doxorubicin
Doxorubicin extravasation:
1000 mg/m IV within 6 hours
2
and again on day 2. Infuse
2
500 mg/m IV on day 3.

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