Page 1498 - Veterinary Immunology, 10th Edition

VetBooks.ir Annotated List of Selected CD

Molecules

Note: Of the 371 currently recognized cell surface CD molecules,
many have no known function or do not play a significant role in

immunity. Most are glycoproteins. This list summarizes the key
features of only the most important.

CD1 A family of class Id MHC-like molecules that are antigen-
presenting molecules for lipids and glycolipids. Found on

thymocytes, macrophages, dendritic cells, NKT cells, and some B
cells.

CD2 Also called LFA-2, this is a cell adherence molecule whose
ligands are CD58 (non-rodents) and CD48 (rodents only). It is
found on T cells and some B cells.

CD3 A collective designation for the signal transducing molecules

of the TCR. They are found only on T cells.

CD4 A receptor for MHC class II molecules that plays a key role in
the recognition of processed antigens by helper T cells. It is
expressed on helper T cells, thymocytes, and monocytes.

CD5 A receptor for CD72. It is found on T cells and a
subpopulation of B cells (B-1a cells) in most species, including
mice and humans, but not on B cells in rats or dogs.

CD8 This dimeric glycoprotein is a receptor for MHC class I
molecules that plays a key role in the recognition of endogenous
antigen. It is expressed on cytotoxic T cells.

CD9 A glycoprotein expressed on platelets, immature B cells,
eosinophils, basophils, and activated T cells.

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