Page 1500 - Veterinary Immunology, 10th Edition

CD25 The α chain of the IL-2 receptor. CD25 associates with the IL-
VetBooks.ir 2Rβ chain (CD122). It is expressed on activated T cells, B cells,

and monocytes. CD25 expression is a feature of regulatory T cells.

CD27 A member of the tumor necrosis factor receptor family and
the ligand of CD70. It is homologous to SWC2.

CD28 The ligand for both CD80 and CD86 that plays a key role in T
cell co-stimulation. It is expressed on activated B cells and other
antigen-presenting cells. It delivers a stimulatory signal to T cells
as opposed to CD152, which delivers a suppressive signal.

CD29 A β integrin expressed on leukocytes and platelets. In
1
conjunction with its α chain (one of the forms of CD49), it binds
these cells to extracellular matrix proteins.

CD31 Mediates adhesion between cells that express CD31 (e.g.,

leukocytes to endothelial cells) in a homophilic manner (CD31
binds CD31 on the apposing cell). It regulates the phagocytosis of
dead and dying cells.

CD32 A medium-affinity IgG receptor also called FcγRII, different

forms of which are expressed on macrophages, granulocytes, and
B cells.

CD33 Siglec-3, a lectin expressed on immature hematopoietic stem
cells.

CD34 Also called sialomucin, this glycoprotein is a ligand for

certain integrins. It is expressed on endothelial cells and some
dendritic cells.

CD35 This is the receptor for the complement components C3b and
C4b, so it is also called CR1. It is expressed on granulocytes,

monocytes, B cells, NK cells, and primate erythrocytes.

CD36 A pattern-recognition receptor that binds many different
ligands, especially lipids. CD36 on intestinal γ/δ T cells binds
bacterial lipoteichoic acids and helps trigger innate responses.
Found on many different cell types.

1500