Page 1628 - Saunders Comprehensive Review For NCLEX-RN

hypersensitivity or with acute liver
disease
b. Use with caution in clients with chronic
liver disease, alcoholism, or renal
impairment.
c. Use with caution in clients taking
nicotinic acid.
d. Use with caution in clients taking
hepatotoxic medications because the
risk for hepatotoxicity increases.
e. Alcohol increases the risk of
hepatotoxicity.
f. May increase the risk of toxicity of
carbamazepine and phenytoin
g. May decrease ketoconazole
concentrations
3. Side and adverse effects
a. Hypersensitivity reactions

b. Peripheral neuritis

c. Neurotoxicity

d. Hepatotoxicity and hepatitis;

increased liver function test levels

e. Pyridoxine deficiency

f. Irritation at injection site with
intramuscular administration
g. Nausea and vomiting
h. Dry mouth
i. Dizziness
j. Hyperglycemia

k. Vision changes

4. Interventions

a. Assess for hypersensitivity.
b. Assess for hepatic dysfunction.
c. Assess for sensitivity to nicotinic acid.
d. Monitor liver function test results.
e. Monitor for signs of hepatitis, such as
anorexia, nausea, vomiting, weakness,
fatigue, dark urine, or jaundice; if these
symptoms occur, withhold the
medication and notify the PHCP.

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