Page 1629 - Saunders Comprehensive Review For NCLEX-RN

f. Monitor for tingling, numbness, or
burning of the extremities.
g. Assess mental status.
h. Monitor for visual changes, and notify
the PHCP if they occur.
i. Assess for dizziness and initiate safety
precautions.
j. Monitor complete blood count (CBC)
and blood glucose levels.
k. Administer isoniazid 1 hour before or 2
hours after a meal, because food may
delay absorption.
l. Administer isoniazid at least 1 hour
before antacids.
m. Administer pyridoxine as prescribed to
reduce the risk of neurotoxicity.

Many tuberculosis medications can cause

toxic effects such as hepatotoxicity, nephrotoxicity,
neurotoxicity, optic neuritis, or ototoxicity. Teach the
client about the signs of toxicity and inform the client
that the PHCP needs to be notified if any signs
arise.

5. Client education

a. To avoid tyramine-containing foods
because they may cause a reaction
such as red and itching skin, a
pounding heartbeat, lightheadedness,
a hot or clammy feeling, or a headache;
if this occurs, the client should notify
the PHCP.
b. To recognize the signs of neurotoxicity,
hepatitis, and hepatotoxicity
c. To notify the PHCP if signs of
neurotoxicity, hepatitis and
hepatotoxicity, or visual changes
occur.
B. Rifampin
1. Description
a. Inhibits bacterial RNA synthesis
b. Binds to DNA-dependent RNA
polymerase and blocks RNA
transcription
c. Used with at least 1 other antitubercular
medication

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