Page 1634 - Saunders Comprehensive Review For NCLEX-RN

XV. Second-Line Medications for Tuberculosis (see Box 51-7)
A. Rifabutin
1. Description
a. Inhibits mycobacterial DNA-dependent
RNA polymerase and suppresses
protein synthesis
b. Used to prevent disseminated
Mycobacterium avium complex (MAC)
disease in clients with advanced HIV
infection
c. Used to treat active MAC disease and
tuberculosis in clients with HIV
infection
2. Cautions
a. Can affect blood levels of some
medications, including oral
contraceptives and some medications
used to treat HIV infection
b. A nonhormonal method of birth control
should be used instead of an oral
contraceptive.
3. Side and adverse effects
a. Rash
b. Gastrointestinal disturbances
c. Neutropenia
d. Red-orange–colored body secretions

e. Uveitis

f. Myositis

g. Arthralgia

h. Hepatitis

i. Chest pain with dyspnea
j. Flu-like syndrome

4. Interventions

a. Observe for hepatotoxic effects; if they
occur, withhold the medication and
notify the PHCP.
b. Assess for painful or swollen joints.
c. Assess for ocular pain or blurred vision.
5. Client education: That the medication can be

taken without regard to food
B. Rifapentine

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