Page 1633 - Saunders Comprehensive Review For NCLEX-RN

2. Contraindications and cautions

a. Contraindicated in clients with
hypersensitivity
b. Used with caution in clients with
diabetes mellitus, renal impairment, or
gout and in children
c. May decrease the effects of allopurinol,
colchicine, and probenecid
d. Cross-sensitivity is possible with
isoniazid, ethionamide, or nicotinic
acid.
3. Side and adverse effects
a. Increases liver function tests and uric
acid levels
b. Arthralgia, myalgia

c. Photosensitivity

d. Hepatotoxicity

e. Thrombocytopenia
4. Interventions
a. Assess for hypersensitivity.
b. Evaluate CBC, liver function test
results, and uric acid levels.

c. Observe for hepatotoxic effects;

if they occur, withhold the medication
and notify the PHCP.
d. Assess for painful or swollen joints.
e. Evaluate blood glucose level, because
diabetes mellitus may be difficult to
control while client is taking the
medication.

5. Client education

a. To take the medication with food to
reduce gastrointestinal distress
b. To avoid sunlight or ultraviolet light
until photosensitivity is determined

Some tuberculosis medications can cause

red- orange–colored body secretions. Inform the
client that this is not a harmful effect but that the
secretions can stain and permanently discolor items.

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