Page 86 - Children Bookt.pdf
P. 86

Z&	"       Systemic illness usually with   Positive microscopy
               disseminated TB       prolonged                     showing AFB or
                                     fever, night sweats, weight loss.   culture of
                                     Clinical                      Mycobacterium
                                     features of organs involved, e.g.   tuberculosis
                                     sterile                       from blood or other
                                     pyuria, pericarditis, ascites,   relevant specimen
                                     pleural                       
&
                                     effusion, meningitis, arthritis,   BAL. Biopsy and
                                     orchitis                      histology
               Kaposi sarcoma        Typical appearance in skin or  Macroscopic
                                     &


    appearance or by
                                     %
                *
                                     patches with a pink or blood-  –
6
                                     bruise                        lesions seen on
                                     colour, skin lesions that usually   bronchoscopy or
                                     develop                       endoscopy;
                                     into nodules                  –
                                                                   lymph nodes,
                                                                   viscera or lungs by
                                                                   palpation or
                                                                   radiology;
                                                                   –
               CMV retinitis or CMV  Retinitis only                
$
               infection             CMV retinitis may be diagnosed  required for other
               affecting another     by                            sites. Histology or
               organ, with onset at   
&


*     CMV demonstrated
               age >1 month          progressive                   in CSF by culture or
                                     %

$
  DNA-PCR
                                     %
                                     and scotoma; typical eye lesions
                                     on
                                     

&	¥
                                     discrete patches of retinal
                                     whitening
                                     with distinct borders, spreading
                                     centrifugally, often following
                                     blood
                                     vessels, associated with retinal
                                     vasculitis, haemorrhage and
                                     necrosis






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