Page 88 - Children Bookt.pdf
P. 88
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Paediatric drug formulations and doses
Pharma-
Age (weight), dose and dose
Name of drug Formulations cokinetic data Other comments
frequency
available
Nucleoside analogue reverse transcriptase inhibitors
- Large volume of syrup not well
tolerated in older children, Syrup
needs storage in glass jars and is
light sensitive
< 4 weeks: 4 mg/kg/dose twice
- Can give with food
daily
Syrup: 10 mg/ml - For children with suspected
nervous system involvement, it
4 weeks to 13 yrs:
Capsules 100mg !&??
!!!
2
Zidovudine 180-240 mg/m /dose twice daily
,250 mg All ages the higher end of the range.
^*
- Capsule can be opened and
j!+ '&
Tablet: 60mg contents dispersed or tablet
300 mg/dose twice daily
300 mg crushed and contents mixed with
small amount of water or food
and immediately taken (solution is
stable at room temperature)
- Do not use with d4T
(antagonistic antiretroviral effect)
- Well tolerated
< 30 days:
- Can give with food
2 mg/kg/dose twice daily
- Store solution at room
temperature (use within one
Lamivudine Oral solution: 10 mg/ml '!&
All ages month of opening)
(3TC) Tablet: 150 mg 4 mg/kg/dose twice daily
- Tablet can be crushed and
contents mixed with small amount
Maximum dose: > 50 kg:
water or food and immediately
150 mg/dose twice daily
taken
$!&!?
?
No liquid available - Tablet can be crushed and
contents mixed with small amount
Fixed-dose
!?' ^* Adolescents and AZT 180-240mg/m2 twice daily of water or food and immediately
combination of
Plus 150 mg 3TC adults 3TC 4mg/kg twice daily taken
^*'
^* }'^*!
'
Plus 30 mg 3TC cannot be dosed accurately in
tablet form
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