Page 92 - Children Bookt.pdf
P. 92
Pharma-
Name of Formulations cokinetic Age (weight), dose and dose Other comments
drug data frequency
available
!:
; Syrup: 30 mg/ml Only for Dose Liquid 19.5mg/kg/day Capsules may be opened
]* (note: syrup children once daily and added to food but have
requires higher over very peppery taste;
doses than 3 yrs Capsule/tablets 15mg/kg/day however, can mix with sweet
capsules, see once daily foods or jam to disguise taste
dosing chart) Can give with food (but avoid
Capsules: 50 mg, Weight more than40kg-600mg after high fat meals which
100 mg, 200 mg once daily increase absorption by 50%)
Best given at bedtime,
Tablets especially in the
200mg/600mg
}
central nervous system side
effects
Drug interactions
Fixed-dose No liquid Adults and d4T 1mg/kg twice a day See comments
combination available adolescents 3TC4mg/kg twice a day under individual drug
of d4T [* ! components.
plus 3TC Tablet: maximum dose of 200mg twice !
[*
[* a day at half of the normal daily
d4T6mg+ dosage, is used for 2
3TC30mg+ weeks to decrease the
[* likelihood of developing
rash.
d4T12mg+
]
!
3TC60mg+
'[*!
?
[*
the morning and d4T + 3TC
in the evening.
d4T30mg+
$+
!
3TC150mg+
rash in the lead-in period,
[*
then remain on half the
dosage until the rash
resolves.
Wait no longer than
28 days for the rash to
resolve, then seek an
alternative regimen.
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