Page 94 - Children Bookt.pdf
P. 94
Pharma-
Name of Age (weight), dose and
Formulations cokinetic Other comments
drug dose frequency
data available
Film coated, tablets
Darunavir Children aged Target dose -should be taken with food
75 mg
^* 6 years 10 -20 mg /kg twice daily. *
! !?
150 mg
or Maximum dose and absorption and should be
300 mg
more ^*} :
}:
&^*
400 mg
*}!&
!^*
600 mg
Once daily dosing should *
not be used in pediatric *
!
patients, ?
^*:
- Parents / carers should be
warned about potential skin
rash
!
&^*!?
observed to cause liver
problems.
!;!
!:
Capsules Children aged Target dose To be used in combination
* 100mg Treatment naive }*
!
!
150mg 3 months - wt 15kg-<25kg: - Recommended for patients
200mg to * * aged 6 to <18 years of age
300mg - wt 25kg-<32kg: - Not to be used in patients
21 years
* * less than 3 months of age
- wt 32kg-<39kg: due to risk of kernicterus.
* *
!
!!
for patients less than 6 years
Treatment experienced of age
- wt 25kg-<32kg: - Dose is based on body
* * weight
- wt 32kg-<39kg: 8.5 mg /kg for weight 15kg to
* * less than 20kg and 7mg/kg
Maximum dose for weight 20kg or more
*' *
once daily
_
