Page 91 - Children Bookt.pdf
P. 91
Non-nucleoside reverse transcriptase inhibitors
Nevirapine Oral suspension: All ages Target dose – maintenance $
!
[* 10 mg/ml
!& administration, avoid use
to maximum dose of 200 mg (see Tuberculosis section)
Tablet: twice daily -Store suspension at room
200 mg Target dose prophylaxis temperature; must shake
50mg Aim for exposure of 100ng/ml well
Birth to 6 weeks of age: - Can give with food
- weight less than 2.5 kg -Tablets are scored and can
10 mg per day be divided into two equal
- weight more than 2.5 kg halves to give a 100 mg
15 mg per day dose;
Age 6 weeks to 6 months -can be crushed and
20 mg per day combined with small
Age 6 months to 9 months amount of water or food and
30 mg per day immediately administered
Age 9 months to end of -MUST WARN PARENTS
breastfeeding ABOUT RASH
40 mg per day -Do not dose escalate if rash
Special considerations on occurs (if
maintenance therapy mild/moderate rash, hold
$
drug; when rash cleared,
days omit the evening dose of restart dosing from beginning
[*$
!
:
of dose escalation; if severe
doses are unequal, rash, discontinue drug)
give the higher dose in the Drug interactions
morning and omit the lower
evening dose.
Maintenance therapy:
target dose is 160 – 200 mg/m 2
given twice daily and adjusted
for more aggressive dosing in
the younger age group.
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