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‡µem Pµ t
k¦m‡bi †h wewµqv P‡µ A¨vwmUvBj Co-A, A·v‡jv A¨vwmwUK A¨vwm‡Wi mv‡_ hy³ n‡q mvBUK A¨vwmW ˆZwi K‡i Ges Pµ †k‡l
A·v‡jv A¨vwmwUK A¨vwmW cyb: ˆZwi n‡q Pµ‡K MwZkxj iv‡L Zv‡K †µem Pµ e‡j| Bs‡iR cÖvY-imvqbwe` m¨vi n¨vÝ †µem& (Sir
Hans Adolf krebs, 1937) G PµwU Avwe®‹vi K‡ib e‡j Zvi bvgvbymv‡i G‡K ‡µme Pµ ejv nq| wZwb G‡K mvBwUªK A¨vwmW Pµ
e‡j AvL¨vwqZ K‡ib, KviY G P‡µi cÖ_g c`v_© nj mvBwUªK A¨vwmW| mvBwUªK A¨vwm‡W wZbwU Kve©w·j (-COOH) MÖæc _vKvq G‡K
eZ©gv‡b UªvBKve©w·wjK A¨vwmW Pµ ev wUwmG Pµ e‡j| †µem P‡µi wewµqv¸‡jv ch©vqµwgKfv‡e wb‡¤ †`Lv‡bv n‡jv -
I. 2-Kve©bwewkó A¨vwmUvBj Co-A, GK AYy cvwb mn‡hv‡M 4-Kve©bwewkó A·v‡jv A¨vwmwUK A¨vwmW Gi mv‡_ hy³ n‡q 6-Kve©bwewkó
mvBwUªK A¨vwmW m„wó K‡i| G wewµqvq Kb‡Wbwms GbRvBg mnvqZv K‡i| wewµqv †k‡l Co-A c„_K n‡q hvq| wewµqvwU GKgyLx|
mvBwUªK A¨vwmW GK AYy cvwb nvwi‡q wmm A¨v‡KvbvBwUK A¨vwmW G cwiYZ nq| G wewµqvq A¨v‡Kvwb‡UR GbRvBg mnvqZv K‡i| wewµqvwU
wØgyLx|
II. wmm A¨v‡KvbvBwUK A¨vwmW GK AYy cvwb MÖnb K‡i
AvB‡mvmvBwUªK A¨vwmW G cwiYZ nq| G wewµqvq
A¨v‡Kvwb‡UR GbRvBg mnvqZv K‡i| wewµqvwU wØgyLx|
III. AvB‡mvmvBwUªK A¨vwmW 2H + nvwi‡q
A·v‡jvmvK&wmwbK A¨vwmW G cwiYZ nq| GLv‡b GK
+
AYy NADP n‡Z GK AYy NADPH+H m„wó nq|
G wewµqvq AvB‡mvmvBwUªK A¨vwmW wWnvB‡WªvwR‡bR
GbRvBg mnvqZv K‡i| wewµqvwU wØgyLx|
IV. A·v‡jvmvK&wmwbK A¨vwmW, GK AYy CO2 nvwi‡q -
wK‡UvMøyUvwiKA¨vwmW G cwiYZ nq| G wewµqvq
Kv‡e©vw·‡jR GbRvBg mnvqZv K‡i| wewµqvwU GKgyLx|
V. -wK‡UvMøyUvwiKA¨vwmW, Co-A Gi mv‡_ wgwjZ
n‡q mvK&wmbvBj Co-A MVb K‡i| GLv‡b GK AYy
CO2 wbM©Z nq Ges NAD n‡Z GK AYy
+
NADH+H m„wó nq| -
wK‡UvMøyUvwiKwWnvB‡WªvwR‡bR GbRvBg G wewµqvq
mnvqZv K‡i| wewµqvwU GKgyLx|
VI. mvK&wmbvBj Co-A Gici Co-A nvwi‡q mvK&wmwbK A¨vwmW G cwiYZ nq| GLv‡b GK AYy ADP /GTP ‡_‡K GK AYy
ATP / GTP ‰Zwi nq| G wewµqvq _v‡qvKvB‡bR GbRvBg mnvqZv K‡i| wewµqvwU wØgyLx|
VII. mvK&wmwbK A¨vwmW `ywU nvB‡Wªv‡Rb AYy nvwi‡q wdDgvwiK A¨vwmW G cwiYZ nq| GLv‡b FAD n‡Z FADH2 ˆZwi nq| G
wewµqvq wWnvB‡WªvwR‡bR GbRvBg mnvqZv K‡i| wewµqvwU wØgyLx|
VIII. wdDgvwiK A¨vwmW GK AYy H2O MÖnb K‡i g¨vwjK A¨vwmW G cwiYZ nq| wdDgv‡iR GbRvBg G wewµqvq mnvqZv K‡i|
wewµqvwU wØgyLx|
+
IX. g¨vwjK A¨vwmW `ywU nvB‡Wªv‡Rb nvwi‡q A·v‡jv A¨vwmwUK A¨vwmW G cwiYZ nq| GLv‡b NAD n‡Z NADH+H ‰Zwi nq|
G wewµqvq wWnvB‡WªvwR‡bR GbRvBg mnvqZv K‡i| wewµqvwU wØgyLx|
A·v‡jv A¨vwmwUK A¨vwmW, A¨vwmUvBj Co-A Gi mv‡_ wgwjZ n‡q cyiivq mvBwUªK A¨vwmW m„wó K‡i Ges GB Pµ Pvjy iv‡L|
B‡jKUªb Uªv݇cvU© wm‡÷g (ETS) t
+
+
mevZ k¦m‡bi †h As‡k NADH+H , NADPH+H , FADH2 n‡Z B‡jK&ªb KZK¸‡jv evn‡Ki gva¨‡g ¯’vbvšÍwiZ nq Ges
B‡jKUª‡bi GB ¯’vbvšÍiKv‡j ATP ‰Zwi I me‡k‡l H2O Drcbœ K‡i Zv‡K B‡jKUªb Uªv݇cvU© wm‡÷g e‡j| gvB‡UvKwÛªqvi
AšÍtAveiYx‡Z NAD, FAD, ‡KvGbRvBg-Q Ges mvB‡Uv‡µvg GbRvBg¸‡jv w`‡q B‡jKUªb cÖevnZš¿ MwVZ| GK‡Rvov B‡jKUªb
ETS Gi mvnv‡h¨ D”Pkw³ gvÎv †_‡K wb¤œkw³ gvÎvq µgvš^‡q ¯’vbvšÍwiZ nq| GB kw³i mvnv‡h¨ ADP I Pi wgwjZ n‡q ATP Drcbœ
nq| B‡jKUªb cÖevnZ‡š¿ ATP ‰Zwii c×wZ‡K Aw·‡WwUf dm‡dvivB‡jkb e‡j|
MøvB‡KvjvBwmm, A¨vwmUvBj †Kv-G m„wó Ges †µem P‡µ Drcbœ NADH2 , NADPH2 Ges FADH2 B‡jKUªb cÖevnZ‡š¿i mvnv‡h¨ RvwiZ n‡q
cybivq NAD , NADP Ges FAD ‡Z cwiYZ nq| &Ww‡jKUªb cÖevnZ‡š¿i gva¨‡g cÖwZwU NADH2 n‡Z 3wU ATP Ges cÖwZwU FADH2 n‡Z
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