Page 1248 - Basic _ Clinical Pharmacology ( PDFDrive )

1234 Index

Phenindione, 614f Phosphate binders, for bone, 790t Pituitary gland, 667, 668f
Phenobarbital, 393t. See also Barbiturates 3′-Phosphoadenosine 5′-phosphosulfate Pituitary hormones, anterior, 668–680,
in neonates, 1053t (PAPS), 63, 64t 682t–684t
seizures treated with, 424, 433t, 436t Phosphodiesterase inhibitors, 363t. See also classification of, 668f, 668–669
structure of, 383f specific drugs dopamine agonists, 679–680, 684t, 685t
teratogenicity of, 434 Phosphoinositides fundamentals, 667
Phenol, 899 description of, 32 GnRH receptor antagonists, 678–679
Phenolics, 899 as second messengers, 32–34, 34f gonadotropin-releasing hormone and
Phenothiazines Phosphoinositide signaling pathway, analogs, 676–678
antiemetic properties of, 1105–1106 32–34, 34f actions of, 676
derivatives of Phosphoramidon, 312 chemistry and pharmacokinetics of,
chemical structure of, 513f, 514–515, Phosphorylation, 32, 33f, 35 676
515t Physical dependence, 389, 575. clinical pharmacology of, 677–678
psychosis treated with, 513f, 514–515, See Dependence, physical pharmacodynamics of, 676–677
515t Physical nature, of drugs, 3 uses of, 676
Phenoxybenzamine, 24, 157f, 159, Physician’s order sheet (POS), 1147 gonadotropins, 673–676
159t, 170t, 184, 291. See also Physiologic antagonism, 25–26 chemistry and pharmacokinetics of,
Adrenoceptor antagonist drugs Physiology, experimental, 2 673–674
Phensuximide, 429f Physostigmine, 122t clinical pharmacology of, 674–675,
Phentermine + topiramate, 289b, 290t absorption of, 115 675f
Phentolamine, 157f–158f, 159, 159t, antimuscarinic intoxication reversal pharmacodynamics of, 674
170t, 184. See also Adrenoceptor using, 120 preparations available, 685t
antagonist drugs chemistry and pharmacokinetics of, toxicity and contraindications to, 676
Phenylbutazone, 644f. See also Nonsteroidal 115–117 growth hormone, 670–672, 671t, 682t
anti-inflammatory drugs (NSAIDs) structure of, 115, 116f growth hormone antagonists, 672–673
Phenylephrine, 141t, 146f, 149, 154t. Phytolacca americana, 1133t fundamentals of, 672
See also Sympathomimetics Picrolimus, 1074–1075 pegvisomant, 672
cardiovascular responses to, 146t Picrotoxin, 370t somatostatin analogs, 672f, 672–673
ganglion blockers on cardiovascular Pigmentation agents, 1076 mecasermin, 672, 682t
response to, 145, 147f Pilocarpine, 109, 113, 122t preparations available, 685t
structure of, 144f salivary secretion using, 119 prolactin, 679
Phenylethylamine, 144f. See also Catechol- structure of, 110f Pituitary hormones, for male contraception,
amines; Sympathomimetics Pimavanserin, 519 745
Phenylheptylamines. See also Opioid Pimozide Pituitary hormones, posterior, 680–682,
agonists chemical structure of, 514f, 515 684t
mild to moderate, 568 drug interactions of, 1170t oxytocin, 680–681, 681f, 684t
strong, 567, 572t psychosis treated with, 515 oxytocin antagonist, 681
Phenylpiperidines. See also Opioid agonists tics treated with, 505, 508t preparations available, 685t
mild to moderate, 568 Pindolol, 164t, 166, 170t. See also structures of, 681f
strong, 568, 572t b-receptor antagonist drugs vasopressin receptor agonists, 681–682,
Phenytoin hypertension treated with, 183 684t, 685t
drug interactions of, 1169t–1170t intrinsic efficacy of, 5 vasopressin receptor antagonists, 682,
in neonates, 1053t structure of, 163f 684t, 685t
seizures treated with, 418f–419f, Pinworms. See also Antihelminthics Pit viper antivenom, 1181t
418–419, 433t, 435t albendazole for, 938–940, 939t Placebo response, 14
Pheochromocytoma mebendazole for, 942 Placental drug metabolism, 1048. See also
alpha-receptor antagonists for, 160–161, pyrantel pamoate for, 945–946 Pregnancy, pharmacology in
161f Pioglitazone, 760, 768t Placental transporters, 1048
case study of, 156, 172 Pipecuronium, 477f. See also Plant systemics, 1011
Philanthotoxin, 370t Neuromuscular blocking drugs Plasma fractions, 621–623, 622t, 624t
pH manipulation, urinary, 1040 Piperaquine, 919f, 920t, 922, 922t Plasma protein binding, 53, 53b
Phocomelia, thalidomide-induced, 1049 Piperazine, 939t, 944 Plasmin, 611f
Phosphate Pirbuterol, 351 Plasminogen activator inhibitor (PAI), 611,
abnormal serum hyperphosphatemia, 784 Piroxicam, 644f, 645t, 648. See also 611f
for bone, 790t Nonsteroidal anti-inflammatory Plasmodium life cycle, 917, 918f
on bone homeostasis, 773, 773f drugs (NSAIDs) Platelet-derived growth factor (PDGF), 27
for hypercalcemia, 783 Pitavastatin, 632–634, 639t Platelets, 329
for hypophosphatemia, 784 Pitolisant (BF2649), 279 Platinum analogs, 955t, 956–957