Page 180 - Physiology and Pathophysiology MNU 2024-2025 نظرى

Clinical pharmacy 2024/2025 Level 2 Pharm D Physiology and Pathophysiology (MD303)
Exercise
a) Heart release 25L/ min ➔ different distribution ➔ decrease blood

flow to another organ
b) 85% Of blood to muscle & decrease blood go to kidney,
1) ↑Sympathetic outflow to the heart and blood
vessels
2) ↓ parasympathetic outflow to the heart ➔
this leads to
(1) the central • ↑heart rate, ↑ contractility , ↑ stroke volume ➔ ↑

command cardiac output
• ↓unstressed volume ➔ ↑ venous return
3) arteriolar constriction in the skin, Splanchnic
regions kidneys and inactive muscles ➔ ↓
blood flow to these organs
(2) metabolic Vasodilator metabolites (e.g lactate) accumulate in
activity of exercising muscle ➔ ↑arteriolar dilation➔ ↑ blood
skeletal flow ➔ ↑O2 delivery to muscle
muscle

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