Page 47 - phytochemistry general program
P. 47
Curare is the crude dried extract of the bark and stems of Chondrodendro .1
species family Menispermaceae .
.2
Curare contains several alkaloids ,the most important are .1
d-tubocurarine (major) .2
Curine (minor).
Both are dimeric alkaloids (bis -benzylisoquinoline alkaloid)
Curare alkaloids
MeO * N MeO *N Me
O Me O
OH H OH H
O O
Me H H
Me OH
NN+ OH Me
N
OMe OMe
(+)-Tubocurarine (-)-Curine
(Bebeerine)
d- (+) tubocurarine chloride
It is a dextrorotatory, quaternary, bis benzylisoquinoline alkaloid, .1
It is insoluble in organic solvents .1
It is soluble in water and in alcohol, .2
? It dissolves in solutions of alkali hydroxide. Why
(-) Curine (bebeerine)
It differs from (+) tubocurarine in being .1
3ry alkaloid. .2
.3
It is soluble in organic solvents.
Insoluble in cold water.
Estimation of d- tubocurarine chloride
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