Page 50 - phytochemistry general program

2- Phenylethylamine group, represented by narceine.

3- Phenanthrene group, including morphine, codeine and thebaine.

Opium alkaloids with benzylisoquinoline nucleus

This group includes the weakly basic alkaloids .1
.2
MeO .3

Papaverine

NMaeOrcotine (noscaNpine)

Papaverine

MeO

OMeProperties

** Papaverine is an aromatic weakly basic, optically inactiPvaep,avcerryinsetalline alkaloid.

** It can be extracted with chloroform from acidic solution.

Papaverine oxalate is insoluble in water and is usually utilized for its .1
separation from other opium alkaloids.

** The therapeutically used salt of papaverine is papaverine hydrochloride

Test for identification
1-Warren’s test for papaverine:
Few crystals of papaverine are crushed with crystal of potassium permenganate
and one drop of Marqui’s reagent. A green colour develops, rapidly changed to

blue.
Assay : By non aqueous titration.

Uses

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