Page 101 - Analytical Chemistry I E-book

Non-Aqueous Titration of Acidic Substances

• Analyte: Very weak acidic substances including carboxylic acids,
amino acids, phenols, sulfonamides and imides such as phenytoin and
barbiturates.

• Titrant: Several titrants can be used such as:
Sodium methoxide (CH3ONa)
Lithium methoxide (CH3OLi)
Tetrabutyl ammonium hydroxide

C4H9 C4H9 _
+ OH

N C4H9

All are dissolved in methCan4Hol9. They are secondary standards that can

be standardized by titration against benzoic acid.