Page 80 - Analytical Chemistry I E-book
P. 80
Some Pharmacopial Applications of Acid-Base Titrations
(from USP, BP, EP)
Determination of acidic drugs
• Carboxylic and sulfonic acid groups are the two most common
structures that impart acidity to organic compounds. Most carboxylic
acids have ionization constants that range between 10–4 and 10–6 ,
and thus these compounds are readily titrated.
R‒SO3H R‒COOH
Carboxylic acid Sulfonic acid
