Page 108 - COMMUNITY PHARMACY PRACTICE
P. 108
02/04/2024
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Lactulose
• Drug interaction
It shouldn't be given concomitantly with locally acting aminoglycoside
antibiotics:
• Administration guidelines (pt counseling)
• It should be taken with fruit juice, water or milk to increase its
palatability
• Other uses
It is used to decrease blood ammonia level in hepatic encephalopathy
N.B. Lactulose may be useful for initial treatment of constipation in
geriatric patients.
Contraindication:
• Galactose(galactosemia) and lactose intolerance (as the preparations
available on the market contain small amounts of galactose and
lactose).
• diabetes mellitus
Side effects?
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221
beta
galactosidas acidific
ation
e
of
lactulose colonic Lactic acid
colon
bacteria
trapping
expels the ammonia NH3 to the
ammonium
trapped and ion (NH4)+
ammonium preventing
ion from Osmotic its
the colon pressure
absorption
.
inc Laxative effect
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